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Normal IPT and IBZM SPECT in drug-naive and levodopa-treated idiopathic restless legs syndrome

*Both authors contributed equally to this article.
From the Department of Neurology (Drs. Eisensehr, Noachtar, and Lindeiner), Department of Nuclear Medicine (Dr. Wetter), Ludwig-Maximilians University, Munich; Max Planck Institute of Psychiatry (Drs. Linke, Gildehaus, and Tatsch), Munich; and the Department of Neurophysiology (Dr. Trenkwalder), University of Göttingen, Germany.

Address correspondence and reprint requests to Dr. Ilonka Eisensehr, Department of Neurology, Ludwig-Maximilians University, Klinikum Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany; e-mail: eisen{at}nefo.med.uni-muenchen.de

Fourteen drug-naive and 11 levodopa-treated patients with idiopathic restless legs syndrome (RLS), and 10 controls age-matched to each RLS group separately were examined with polysomnography (PSG), [¹²³I]-(N)-(3-iodopropen-2-yl)-2ß-carbomethoxy-3ß-(4-chlorophenyl) tropane (¹²³I-IPT) SPECT, and [¹²³I]-(S)-2-hydroxy-3-iodo-6-methoxy-[(1-ethyl-2-pyrrolidinyl)methyl] benzamide (¹²³I-IBZM) SPECT. Drug-naive and levodopa-treated patients with RLS and controls showed similar striatal dopamine transporter and dopamine D₂-receptor binding, the latter declining with age. The authors conclude that striatal dopamine transporter and receptor density is normal in drug-naive and levodopa-treated patients with RLS.

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