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Neurology 2001;57:1313-1316
© 2001 American Academy of Neurology
Brief Communications

Long-term treatment with recombinant nerve growth factor for HIV-associated sensory neuropathy

G. Schifitto, MD, C. Yiannoutsos, PhD, D. M. Simpson, MD, B. T. Adornato, MD, E. J. Singer, MD, H. Hollander, MD, C. M. Marra, MD, M. Rubin, MD, B. A. Cohen, MD, T. Tucker, MD, I. J. Koralnik, MD, D. Katzenstein, MD, B. Haidich, MSc, M. E. Smith, MD, S. Shriver, MS, L. Millar, BS, D. B. Clifford, MD, J. C. McArthur, MBBS MPH and the AIDS Clinical Trials Group Team 291

*See the Appendix on page 1315 for a complete listing of the members of the AIDS Clinical Trials Group Team 291.
From the Department of Neurology (Dr. Schifitto), University of Rochester, NY; Harvard School of Public Health (Dr. Yiannoutsos and B. Haidich), Boston, MA; Department of Neurology (Dr. Simpson), Mount Sinai School of Medicine, New York, NY; Departments of Neurology (Dr. Adornato) and Medicine (Dr. Katzenstein), Stanford University, CA; Department of Neurology (Dr. Singer), University of California, Los Angeles; Department of Medicine (Dr. Hollander), University of California, San Francisco; Department of Neurology (Dr. Marra), University of Washington, Seattle; Department of Neurology (Dr. Rubin), Cornell University, New York, NY: Department of Neurology (Dr. Cohen), Northwestern University, Chicago, IL; Department of Neurology (Dr. Tucker), Case Western Reserve University, Cleveland, OH; Department of Neurology (Dr. Koralnik), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Departments of Neurology and Epidemiology (Dr. McArthur), Johns Hopkins University, Baltimore, MD; National Institute of Allergy and Infectious Diseases (Dr. Smith), Bethesda, MD; AIDS Clinical Trials Group Operations (S. Shriver), Rockville, MD; Frontier Science and Technology Research Foundation (L. Millar), Amherst, NY; and Department of Neurology (Dr. Clifford), Washington University, St. Louis, MO.

Address correspondence and reprint requests to Dr. Giovanni Schifitto, University of Rochester, Department of Neurology, 601 Elmwood Avenue, Box 673, Rochester, NY 14642; e-mail: gschifitto{at}mct.rochester.edu

HIV-associated distal sensory polyneuropathy (DSP) is a common complication of AIDS. No effective treatment is available. The authors investigated the long-term effect (48 weeks) of the neurotrophin nerve growth factor (NGF) in an open-label study of 200 subjects with HIV-associated DSP. Similar to their previously reported double-blind study, the authors showed that NGF was safe and well tolerated and significantly improved pain symptoms. However, there was no improvement of neuropathy severity as assessed by neurologic examination, quantitative sensory testing, and epidermal nerve fiber density.




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