Neurology 2001;57:1392-1396
© 2001 American Academy of Neurology
Articles
Daytime sleepiness and other sleep disorders in Parkinson’s disease
W. G. Ondo, MD,
K. Dat Vuong, MA,
H. Khan,
F. Atassi, MPH,
C. Kwak, MS PA-C and
J. Jankovic, MD
From the Baylor College of Medicine, Department of Neurology, Houston, TX.
Address correspondence and reprint requests to Dr. William Ondo, 6550 Fannin, Ste 1801, Houston, TX 77030; e-mail: wondo{at}bcm.tmc.edu
Background:— PD is associated with a variety of sleep problems. The dopamine agonists (DA) pramipexole and ropinirole were recently implicated in causing "sleep attacks" and motor vehicle accidents.
Methods:— In order to determine the overall rate of subjective sleep problems in PD and to determine if any factors, including specific medications, correlate with sleep pathology, the authors surveyed consecutive patients with PD seen over a 3-month period in a Movement Disorders Clinic. The authors collected demographic and medication data, and the patients completed the Epworth Sleepiness Scale (ESS), questions assessing the presence of restless legs syndrome (RLS), a modified National Sleep Foundation sleep survey, and specific questions regarding falling asleep while driving.
Results:— A total of 320 patients completed the questionnaire. The authors eliminated 17, six for incomplete data and 11 for having a primary diagnosis other than PD. The mean age of the remaining 303 patients was 67.1 ± 10.7 years, and the mean duration of PD was 9.1 ± 5.7 years. The ESS scores averaged 11.1 ± 5.9, and in 50.2% of patients the score was abnormally high (>10). Stepwise regression analysis found that sleepiness correlated with longer duration of PD (p < 0.001), more advanced PD (p < 0.004), male sex (p < 0.001), and the use of any DA (p < 0.003). The soporific effects of the three most common DA (pramipexole, ropinirole, and pergolide) were similar. Falling asleep while driving was reported by 63/279 (22.6%) of current drivers and correlated with higher ESS scores (p < 0.05). Other sleep disorders, including RLS, were also frequently reported.
Conclusion: — Daytime sleepiness is common in PD and correlates with more advanced and longer duration of PD, and male sex. The DA were also independently associated with daytime sleepiness, but in this group, no single DA was more culpable than the others.
This article has been cited by other articles:
|
|
|
|
 
Y. Compta, J. Santamaria, L. Ratti, E. Tolosa, A. Iranzo, E. Munoz, F. Valldeoriola, R. Casamitjana, J. Rios, and M. J. Marti
Cerebrospinal hypocretin, daytime sleepiness and sleep architecture in Parkinson's disease dementia
Brain,
December 1, 2009;
132(12):
3308 - 3317.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. W. Olanow, M. B. Stern, and K. Sethi
The scientific and clinical basis for the treatment of Parkinson disease (2009)
Neurology,
May 26, 2009;
72(21_Supplement_4):
S1 - S136.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. PANDYA, C. S. KUBU, and M. L. GIROUX
Parkinson disease: Not just a movement disorder
Cleveland Clinic Journal of Medicine,
December 1, 2008;
75(12):
856 - 864.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. G. Ondo, T. Perkins, T. Swick, K. L. Hull Jr, J. E. Jimenez, T. S. Garris, and D. Pardi
Sodium Oxybate for Excessive Daytime Sleepiness in Parkinson Disease: An Open-Label Polysomnographic Study
Arch Neurol,
October 1, 2008;
65(10):
1337 - 1340.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J Jankovic
Parkinson's disease: clinical features and diagnosis
J. Neurol. Neurosurg. Psychiatry,
April 1, 2008;
79(4):
368 - 376.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ryan and J. T. Slevin
Restless Legs Syndrome
Journal of Pharmacy Practice,
December 1, 2007;
20(6):
430 - 448.
[Abstract]
[PDF]
|
|
|
|
|
|
|
K. M. Biglan, R. G. Holloway Jr, M. P. McDermott, I. H. Richard, and The Parkinson Study Group CALM-PD Investigators
Risk factors for somnolence, edema, and hallucinations in early Parkinson disease
Neurology,
July 10, 2007;
69(2):
187 - 195.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. D. Gjerstad, G. Alves, T. Wentzel-Larsen, D. Aarsland, and J. P. Larsen
Excessive daytime sleepiness in Parkinson disease: is it the drugs or the disease?
Neurology,
September 12, 2006;
67(5):
853 - 858.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Dhawan, D. G. Healy, S. Pal, and K. R. Chaudhuri
Sleep-related problems of Parkinson's disease.
Age Ageing,
May 1, 2006;
35(3):
220 - 228.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W G Ondo, R Fayle, F Atassi, and J Jankovic
Modafinil for daytime somnolence in Parkinson's disease: double blind, placebo controlled parallel trial
J. Neurol. Neurosurg. Psychiatry,
December 1, 2005;
76(12):
1636 - 1639.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Avorn, S. Schneeweiss, L. R. Sudarsky, J. Benner, Y. Kiyota, R. Levin, and R. J. Glynn
Sudden Uncontrollable Somnolence and Medication Use in Parkinson Disease
Arch Neurol,
August 1, 2005;
62(8):
1242 - 1248.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. H. Adler and M. J. Thorpy
Sleep issues in Parkinson's disease
Neurology,
June 28, 2005;
64(12_suppl_3):
S12 - S20.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. B. Rye
Relief in sight for restless legs syndrome
Neurology,
December 28, 2004;
63(12):
2213 - 2214.
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. B. Rye
The two faces of Eve: Dopamine's modulation of wakefulness and sleep
Neurology,
October 26, 2004;
63(8_suppl_3):
S2 - S7.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
C. Serrano and D. Garcia-Borreguero
Fluctuations in cognition and alertness in Parkinson's disease and dementia
Neurology,
October 26, 2004;
63(8_suppl_3):
S31 - S34.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
P. Barone, M. Amboni, C. Vitale, and V. Bonavita
Treatment of nocturnal disturbances and excessive daytime sleepiness in Parkinson's disease
Neurology,
October 26, 2004;
63(8_suppl_3):
S35 - S38.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
B. Phillips
Movement disorders: A sleep specialist's perspective
Neurology,
March 9, 2004;
62(90052):
S9 - 16.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. Razmy, A. E. Lang, and C. M. Shapiro
Predictors of Impaired Daytime Sleep and Wakefulness in Patients With Parkinson Disease Treated With Older (Ergot) vs Newer (Nonergot) Dopamine Agonists
Arch Neurol,
January 1, 2004;
61(1):
97 - 102.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. R. Chaudhuri
Nocturnal symptom complex in PD and its management
Neurology,
September 23, 2003;
61(90063):
S17 - 23.
[Full Text]
|
|
|
|
|
|
|
K R Chaudhuri, S Pal, A DiMarco, C Whately-Smith, K Bridgman, R Mathew, F R Pezzela, A Forbes, B Hogl, and C Trenkwalder
The Parkinson's disease sleep scale: a new instrument for assessing sleep and nocturnal disability in Parkinson's disease
J. Neurol. Neurosurg. Psychiatry,
December 1, 2002;
73(6):
629 - 635.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.N. Homann, M. Forstner, G. Ivanic, E. Ott, W. G. Ondo, and J. Jankovic
Daytime sleepiness and other sleep disorders in Parkinson's disease
Neurology,
June 25, 2002;
58(12):
1863 - 1864.
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. E. O'Suilleabhain and R. B. Dewey Jr
Contributions of Dopaminergic Drugs and Disease Severity to Daytime Sleepiness in Parkinson Disease
Arch Neurol,
June 1, 2002;
59(6):
986 - 989.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. D. Gjerstad, D. Aarsland, and J. P. Larsen
Development of daytime somnolence over time in Parkinson's disease
Neurology,
May 28, 2002;
58(10):
1544 - 1546.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. B. Rye and J. Jankovic
Emerging views of dopamine in modulating sleep/wake state from an unlikely source: PD
Neurology,
February 12, 2002;
58(3):
341 - 346.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. L. Comella
Daytime Sleepiness, Agonist Therapy, and Driving in Parkinson Disease
JAMA,
January 23, 2002;
287(4):
509 - 511.
[Full Text]
[PDF]
|
|
|
Correspondence:
Read all Correspondence
- Daytime sleepiness and other sleep disorders in Parkinson’s disease
- Homann C N, et al.
- Neurology Online, 2 Apr 2002
[Full text]
- Reply to Letter to the Editor
- William G Ondo, et al.
- Neurology Online, 2 Apr 2002
[Full text]
|
