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 Volume 57, Number 8, October 23, 2001
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Right arrow Diagnostic test assessment
Right arrow Parkinson's disease/Parkinsonism
Right arrow Dementia with Lewy bodies
Neurology 2001;57:1497-1499
© 2001 American Academy of Neurology
Brief Communications

Improved accuracy of clinical diagnosis of Lewy body Parkinson’s disease

Andrew J. Hughes, MD FRACP;, Susan E. Daniel, BSc MD, FRCPath and Andrew J. Lees, MD FRCP

From The United Kingdom Parkinson’s Disease Society Brain Research Centre (Drs. Hughes, Daniel, and Lees), Institute of Neurology, London, UK; and Neurology Department (Dr. Hughes), Austin and Repatriation Medical Centre, Heidelberg, Australia.

Address correspondence and reprint requests to Dr. Andrew J. Lees, The Reta Lila Weston Institute of Neurological Studies, Royal Free and University College London Medical School, Windeyer Building, 46 Cleveland St, London W1, UK; e-mail: a.lees{at}ion.ucl.ac.uk

The authors studied the accuracy of clinical diagnosis of idiopathic PD (IPD) in 100 consecutive clinically diagnosed cases that came to neuropathological examination. Ninety fulfilled pathologic criteria for IPD. Ten were misdiagnosed: multiple system atrophy (six), progressive supranuclear palsy (two), post-encephalitic parkinsonism (one), and vascular parkinsonism (one). Assessment of the clinical features suggests that an accuracy of 90% may be the highest that can be expected using current diagnostic criteria.




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