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Prospective study of local cutaneous reactions in patients receiving IV phenytoin

From the Australian Centre for Clinical Neuropharmacology (Drs. O’Brien and Vajda, and F.M. Meara), Victorian Epilepsy Centre (Dr. O’Brien) and Pharmacy Department (H. Matthews), St. Vincent’s Hospital Melbourne, and The Department of Medicine (Drs. O’Brien and Vajda), The University of Melbourne, Victoria, Australia.

Address correspondence and reprint requests to Dr. Terence J. O’Brien, Australian Centre for Clinical Neuropharmacology, St. Vincent’s Hospital Melbourne, 41 Victoria Parade, Fitzroy, Victoria, 3065, Australia; e-mail: obrientj{at}svhm.org.au

The authors prospectively examined the occurrence of subacute local cutaneous reactions (LCR) in patients receiving IV phenytoin over a 12-month period at a general hospital. LCR were detected in 29 of 115 patients (25.2%; 22 mild and seven moderate). All resolved within 3 weeks. Patients with LCR were older (median 68 versus 54.5 years, p = 0.004), were more likely to be in a general ward (86% versus 66%, p = 0.04), and had larger catheters (median 16 G versus 18 G, p = 0.05). The authors conclude that LCR are common in routine hospital practice, but are generally mild and benign.

This article has been cited by other articles:

				J. G. Burneo, G. L. Barkley, T. J. O'Brien, and F. J. Vajda Prospective study of local cutaneous reactions in patients receiving IV phenytoin Neurology, April 9, 2002; 58(7): 1134 - 1134. [Full Text] [PDF]

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