| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Department of Neurology (Drs. Semenchuk and Sherman) and the Pain Clinic (Dr. Davis), University of Arizona, Tucson.
Address correspondence and reprint requests to Dr. Semenchuk, 9030 North Silvermoon Way, Tucson, AZ 85743; e-mail: Marilyn.R.Semenchuk{at}gsk.com
Objective:— To evaluate the effectiveness and safety of bupropion sustained-release (SR) for the treatment of neuropathic pain.
Method:— This single-center, outpatient, randomized, double-blind, placebo-controlled, crossover study consisted of two phases. Forty-one nondepressed patients with neuropathic pain spent 6 weeks in each phase in random order and received identical tablets of 150 mg bupropion SR or placebo. Patients were instructed to take one tablet once daily for 1 week followed by one tablet twice daily for 5 weeks.
Results:— While the patients took bupropion SR, neuropathic pain relief was improved or much improved in 30 (73%) patients, and one of these patients became pain-free. The mean average pain score at baseline was 5.7, which remained unchanged at the end of week 6 with placebo, but decreased by 1.7 points to 4.0 (p < 0.001) during therapy with bupropion SR. Pain relief with bupropion SR was significant at week 2 (p < 0.05) and continued throughout weeks 3 through 6 (p < 0.001). A significant decrease in interference of pain on quality of life was observed while patients were receiving bupropion SR compared with placebo. Side effects experienced with bupropion SR were not dose-limiting and consisted primarily of dry mouth, insomnia, headache, gastrointestinal upset, tremor, constipation, and dizziness.
Conclusion:— This placebo-controlled crossover trial showed that bupropion SR (150–300 mg daily) was effective and well tolerated for the treatment of neuropathic pain.
This article has been cited by other articles:
|
|
 |
|
  P. A. Krieter, M. Gohdes, T. J. Musick, F. P. Duncanson, and W. E. Bridson Pharmacokinetics, Disposition, and Metabolism of Bicifadine in Humans Drug Metab. Dispos., February 1, 2008; 36(2): 252 - 259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Ullman Diabetes and Depression Combo Poses Management Challenge DOC News, June 1, 2007; 4(6): 1 - 21. [Full Text]
|
|
|
|
 |
|
 J. M. Lyness End-of-Life Care: Issues Relevant to the Geriatric Psychiatrist Focus, January 1, 2007; 5(4): 459 - 471. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. VADALOUCA, I. SIAFAKA, E. ARGYRA, E. VRACHNOU, and E. MOKA Therapeutic Management of Chronic Neuropathic Pain: An Examination of Pharmacologic Treatment Ann. N.Y. Acad. Sci., November 1, 2006; 1088(1): 164 - 186. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Fink and A. L. Oaklander Small-fiber neuropathy: answering the burning questions. Sci. Aging Knowl. Environ., February 15, 2006; 2006(6): pe7 - pe7. [Abstract] [Full Text]
|
|
|
|
 |
|
 G. A. Irving Contemporary assessment and management of neuropathic pain Neurology, June 28, 2005; 64(12_suppl_3): S21 - S27. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Lyness End-of-Life Care: Issues Relevant to the Geriatric Psychiatrist Focus, April 1, 2005; 3(2): 341 - 353. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Scott and M. J. Kothari Evaluating the Patient with Peripheral Nervous System Complaints J Am Osteopath Assoc, February 1, 2005; 105(2): 71 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Lyness End-of-Life Care: Issues Relevant to the Geriatric Psychiatrist Am J Geriatr Psychiatry, October 1, 2004; 12(5): 457 - 472. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Lussier, A. G. Huskey, and R. K. Portenoy Adjuvant Analgesics in Cancer Pain Management Oncologist, September 1, 2004; 9(5): 571 - 591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Amato and A. L. Oaklander Case 16-2004 - A 76-Year-Old Woman with Numbness and Pain in the Feet and Legs N. Engl. J. Med., May 20, 2004; 350(21): 2181 - 2189. [Full Text] [PDF]
|
|
|
|
 |
|
 R. H. Dworkin, M. Backonja, M. C. Rowbotham, R. R. Allen, C. R. Argoff, G. J. Bennett, M. C. Bushnell, J. T. Farrar, B. S. Galer, J. A. Haythornthwaite, et al. Advances in Neuropathic Pain: Diagnosis, Mechanisms, and Treatment Recommendations Arch Neurol, November 1, 2003; 60(11): 1524 - 1534. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Rock and A. DeMichele Nutritional Approaches to Late Toxicities of Adjuvant Chemotherapy in Breast Cancer Survivors J. Nutr., November 1, 2003; 133(11): 3785S - 3793. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Mendell and Z. Sahenk Painful Sensory Neuropathy N. Engl. J. Med., March 27, 2003; 348(13): 1243 - 1255. [Full Text] [PDF]
|
|
|
|
 |
|
 Sustained-Release Bupropion for Neuropathic Pain Journal Watch Gastroenterology, February 13, 2002; 2002(213): 11 - 11. [Full Text]
|
|
|
|
 |
|
 Bupropion Eases Neuropathic Pain Journal Watch Psychiatry, December 20, 2001; 2001(1220): 5 - 5. [Full Text]
|
|
|
|
 |
|
 Sustained-Release Bupropion for Neuropathic Pain Journal Watch (General), December 14, 2001; 2001(1214): 2 - 2. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
