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From the Departments of Neurology (Drs. Smith and Singleton), and Pathology (Dr. Smith, and P. Ramachandran and S. Tripp), University of Utah, Salt Lake City.
Address correspondence and reprint requests to Dr. A. Gordon Smith, University of Utah Department of Neurology, 50 North Medical Drive 3R152, Salt Lake City, UT 84132; e-mail: gordon.smith{at}hsc.utah.edu
The authors describe skin biopsy findings in patients with peripheral neuropathy associated with diabetes and impaired glucose tolerance (IGT). Six patients with IGT, eight with early diabetes-associated neuropathy, and five controls were recruited. Most subjects underwent nerve conduction studies (NCS) and quantitative sensory tests (QST). Skin biopsy was abnormal in all neuropathy subjects and correlated poorly with NCS. Neuropathy associated with IGT primarily affects small fibers and is similar to early diabetes-associated neuropathy.
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