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Neurology 2001;57:1707-1708
© 2001 American Academy of Neurology


Brief Communications

Persistent facial myokymia associated with K+ channel antibodies

Ludwig Gutmann, MD, John G. Tellers, MD and Steven Vernino, MD

From the Department of Neurology (Drs. Gutmann and Tellers), West Virginia University, Morgantown; and Department of Neurology (Dr. Vernino), Mayo Clinic, Rochester, MN.

Address correspondence and reprint requests to Dr. L. Gutmann, Department of Neurology, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506; e-mail: lgutmann{at}wvu.edu

A 58-year-old woman developed bilateral facial myokymia in 1978, persisting for the next 23 years and associated with high titers of voltage-gated K+ channel (VGKC) antibodies. Brain imaging failed to show a pontine lesion. The clinical facial myokymia and electromyographic doublets and multiplets (43 to 250 Hz) were milder and more restricted than those seen in generalized neuromyotonic disorders with VGKC antibodies. This case and another reported recently represent a focal VGKC antibody syndrome.




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