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Neurology 2001;57:1709-1711
© 2001 American Academy of Neurology
Brief Communications

Visualization of denervated muscle by gadolinium-enhanced MRI

Martin Bendszus, MD and Martin Koltzenburg, MD

From the Departments of Neuroradiology (Dr. Bendszus) and Neurology (Dr. Koltzenburg), University of Würzburg, Germany.

Address correspondence and reprint requests to Dr. M. Bendszus, Department of Neuroradiology, University of Würzburg, Josef-Schneider-Str.11, D-97080 Würzburg, Germany; e-mail: bendszus{at}neuroradiologie.uni-wuerzburg.de

Thirty patients presenting with foot drop due to lesions of the peroneal nerve or L5 spinal root were investigated with gadolinium (Gd)-enhanced MRI of the lower leg. Significant enhancement was only seen in the denervated muscles in a pattern appropriate for the distribution of the nerve or root. In a rat model, identical changes in the denervated muscle were reproduced and seen as early as 24 hours after sciatic nerve transection. Thus, Gd-enhanced MRI is a new and sensitive technique to visualize denervated muscle.




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