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 Volume 58, Number 1, January 08, 2002
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Neurology 2002;58:130-133
© 2002 American Academy of Neurology
Brief Communications

Cerebral vasoconstriction and stroke after use of serotonergic drugs

A. B. Singhal, MD, V. S. Caviness, MD, A. F. Begleiter, MD, E. J. Mark, MD, G. Rordorf, MD and W. J. Koroshetz, MD

From the Departments of Neurology (Drs. Singhal, Caviness, Begleiter, Rordorf, and Koroshetz) and Pathology (Dr. Mark), Massachusetts General Hospital, Boston, MA.

Address correspondence and reprint requests to Dr. A.B. Singhal, Stroke Service, VBK-802, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114; e-mail: asinghal{at}partners.org

Serotonin (5-hydroxytryptamine) is a potent vasoconstrictor amine. The authors report three patients who developed thunderclap headache, reversible cerebral arterial vasoconstriction, and ischemic strokes (i.e., the Call–Fleming syndrome). The only cause for vasoconstriction was recent exposure to serotonergic drugs in all patients, and to pseudoephedrine in one patient. These cases, and the literature, suggest that the use of serotonin-enhancing drugs can precipitate a cerebrovascular syndrome due to reversible, multifocal arterial narrowing.




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Correspondence:

Read all Correspondence

Serotonergic drugs and stroke
Denis J Petro, et al.
Neurology Online, 9 Apr 2002 [Full text]
Re: Serotonergic drugs and stroke
Aneesh B. Singhal
Neurology Online, 29 Apr 2002 [Full text]
Cerebral vasoconstriction and stroke after use of serotonergic drugs
Gordon J Gilbert
Neurology Online, 29 Apr 2002 [Full text]
Reply to Letter to the Editor
Aneesh Singhal
Neurology Online, 29 Apr 2002 [Full text]

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