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From the Schools of Psychiatry (Drs. Sachdev, Brodaty, and Looi, and M. Valenzuela) and Medicine (Dr. Wang), University of New South Wales, Australia; Neuropsychiatric Institute (Dr. Sachdev and M. Valenzuela), Academic Department for Old Age Psychiatry (Dr. Brodaty), and Department of Cardiovascular Genetics (Dr. Wang), The Prince of Wales Hospital, and Department of Aged Care (Dr. Looi), St George Hospital, Sydney, Australia; and Department of Genetics (Dr. Wang), Southwestern Foundation for Biomedical Research, San Antonio, TX.
Address correspondence and reprint requests to Dr. Perminder Sachdev, NPI, Prince of Wales Hospital, Randwick NSW 2031, Australia; e-mail: p.sachdev{at}unsw.edu.au
The authors examined the association of total plasma homocysteine (Hcy) levels with measures of atrophy and white matter disease on MRI scans in 36 healthy elderly individuals. Hcy had a significant positive relationship with lateral ventricle–brain ratios in the anterior (r = 0.49) and middle (r = 0.43) ventricular regions as measures of central atrophy, but not with cortical atrophy or white matter hyperintensities. In a logistic regression analysis, elevated Hcy was a significant determinant of increased anterior ventricle–brain ratio (
0.34) after controlling for age, folate, B12, creatinine, and white matter disease (OR = 2.3; CI, 1.03–5.09).
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