Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Saunders–Pullman, R.
Right arrow Articles by Bressman, S. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Saunders–Pullman, R.
Right arrow Articles by Bressman, S. B.
Related Collections
Right arrow Dystonia
Right arrow Myoclonus
Right arrow Alcohol
Neurology 2002;58:242-245
© 2002 American Academy of Neurology

Myoclonus dystonia

Possible association with obsessive–compulsive disorder and alcohol dependence

R. Saunders–Pullman, MD MPH;, J. Shriberg, MS MPH;, G. Heiman, MS, D. Raymond, MS, K. Wendt, MPH, P. Kramer, PhD, K. Schilling, MS, R. Kurlan, MD, C. Klein, MD, L. J. Ozelius, PhD, N. J. Risch, PhD and S. B. Bressman, MD

From the Department of Neurology (Drs. Saunders–Pullman and Bressman, and J. Shriberg, D. Raymond, and K. Wendt), Beth Israel Medical Center, Department of Neurology (Drs. Saunders-Pullman and Bressman), Albert Einstein College of Medicine, School of Public Health (G. Heiman), Columbia University, Molecular Genetics Department (Dr. Ozelius), Albert Einstein College of Medicine, New York, NY; Department of Neurology (Dr. Kramer and K. Schilling), Oregon Health Sciences University, Portland; Department of Neurology (Dr. Kurlan), University of Rochester School of Medicine, NY; Department of Neurology (Dr. Klein), Medical University of Lübeck, Germany; and Department of Genetics (Dr. Risch), Stanford University, Stanford, CA.

Address correspondence and reprint requests to Dr. Rachel Saunders–Pullman, Department of Neurology, PACC, Beth Israel Medical Center, Suite 5J, 10 Union Square East, New York, NY 10003; e-mail: rsaunder{at}bethisraelny.org

Background: Inherited myoclonus–dystonia (M-D) is a disorder that is characterized primarily by myoclonic jerks and is often accompanied by dystonia. In addition to motor features, psychiatric disease is reported in some families.

Methods: To determine whether the same genetic etiology underlies both neurologic and psychiatric signs, the authors studied psychiatric symptoms in nonmanifesting carriers (NMC), noncarriers (NC), and manifesting carriers (MC) in three families demonstrating linkage of M-D to the 7q21 locus. Interviewers administered the computerized version of the Composite International Diagnostic Interview. Algorithms for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition diagnosis of obsessive–compulsive disorder (OCD), generalized anxiety disorder, major affective disorder, alcohol abuse, alcohol dependence, drug abuse, and drug dependence were used. Rates of disorders among the MC, NMC, and NC were compared.

Results: Of 55 participating individuals, 16 were MC, 11 were NMC, and 28 were NC. The rate of OCD was greater in carriers (5/27) compared with NC (0/28) (p = 0.023). It was also greater in the symptomatic gene carriers (4/16) compared with the asymptomatic group (1/11) (p = 0.022). Alcohol dependence was increased in the symptomatic carriers (7/16) (p = 0.027), but not in the carrier group overall (7/27).

Conclusion: OCD may be associated with the DYT11 M-D gene; however, a larger sample is necessary to confirm this finding. Alcohol dependence is highly associated with expressing symptoms of M-D. This may be explained by self-medication with alcohol to improve motor symptoms of M-D.




This article has been cited by other articles:


Home page
 J. Neurol. Neurosurg. PsychiatryHome page
R Lencer, S Steinlechner, J Stahlberg, H Rehling, M Orth, T Baeumer, H-J Rumpf, C Meyer, C Klein, A Muenchau, et al.
Primary focal dystonia: evidence for distinct neuropsychiatric and personality profiles
J. Neurol. Neurosurg. Psychiatry, October 1, 2009; 80(10): 1176 - 1179.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
A. Brashear, W. B. Dobyns, P. de Carvalho Aguiar, M. Borg, C. J. M. Frijns, S. Gollamudi, A. Green, J. Guimaraes, B. C. Haake, C. Klein, et al.
The phenotypic spectrum of rapid-onset dystonia-parkinsonism (RDP) and mutations in the ATP1A3 gene
Brain, March 1, 2007; 130(3): 828 - 835.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
C. W. Hess, D. Raymond, P. d. C. Aguiar, S. Frucht, J. Shriberg, G. A. Heiman, R. Kurlan, C. Klein, S. B. Bressman, L. J. Ozelius, et al.
Myoclonus-dystonia, obsessive-compulsive disorder, and alcohol dependence in SGCE mutation carriers
Neurology, February 13, 2007; 68(7): 522 - 524.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
F. Yokoi, M. T. Dang, J. Li, and Y. Li
Myoclonus, Motor Deficits, Alterations in Emotional Responses and Monoamine Metabolism in {varepsilon}-Sarcoglycan Deficient Mice
J. Biochem., July 1, 2006; 140(1): 141 - 146.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
S Tezenas du Montcel, F Clot, M Vidailhet, E Roze, P Damier, C P Jedynak, A Camuzat, A Lagueny, L Vercueil, D Doummar, et al.
Epsilon sarcoglycan mutations and phenotype in French patients with myoclonic syndromes
J. Med. Genet., May 1, 2006; 43(5): 394 - 400.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
S. J. Frucht, W. C. Houghton, Y. Bordelon, P. E. Greene, and E. D. Louis
A single-blind, open-label trial of sodium oxybate for myoclonus and essential tremor.
Neurology, December 27, 2005; 65(12): 1967 - 1969.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
G. A. Heiman, R. Ottman, R. J. Saunders-Pullman, L. J. Ozelius, N. J. Risch, and S. B. Bressman
Increased risk for recurrent major depression in DYT1 dystonia mutation carriers
Neurology, August 24, 2004; 63(4): 631 - 637.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
K. Hedrich, E. -M. Meyer, B. Schule, N. Kock, P. de Carvalho Aguiar, K. Wiegers, J. H. Koelman, J. Garrels, R. Durr, L. Liu, et al.
Myoclonus-dystonia: Detection of novel, recurrent, and de novo SGCE mutations
Neurology, April 13, 2004; 62(7): 1229 - 1231.
[Full Text] [PDF]

Home page
 NeurologyHome page
E. M.J. Foncke, C. Klein, J. H.T.M. Koelman, P. L. Kramer, K. Schilling, B. Muller, J. Garrels, P. de Carvalho Aguiar, L. Liu, A. de Froe, et al.
Hereditary myoclonus-dystonia associated with epilepsy
Neurology, June 24, 2003; 60(12): 1988 - 1990.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
Y. Furukawa and A. H. Rajput
Inherited myoclonus-dystonia: How many causative genes and clinical phenotypes?
Neurology, October 22, 2002; 59(8): 1130 - 1131.
[Full Text] [PDF]

Home page
 NeurologyHome page
D. O. Doheny, M. F. Brin, C. E. Morrison, C. J. Smith, R. H. Walker, S. Abbasi, B. Muller, J. Garrels, L. Liu, P. de Carvalho Aguiar, et al.
Phenotypic features of myoclonus-dystonia in three kindreds
Neurology, October 22, 2002; 59(8): 1187 - 1196.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
D. Doheny, F. Danisi, C. Smith, C. Morrison, M. Velickovic, D. de Leon, S. B. Bressman, J. Leung, L. Ozelius, C. Klein, et al.
Clinical findings of a myoclonus-dystonia family with two distinct mutations
Neurology, October 22, 2002; 59(8): 1244 - 1246.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2002 by AAN Enterprises, Inc.