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Neurology 2002;58:305-307
© 2002 American Academy of Neurology
Brief Communications

Frontocortical N-acetylaspartate reduction associated with long-term IV heroin use

R. Haselhorst, PhD, K. M. Dürsteler–MacFarland, MA, K. Scheffler, PhD, D. Ladewig, MD, F. Müller–Spahn, MD, R. Stohler, MD, J. Seelig, PhD and E. Seifritz, MD

From Biocenter (Drs. Haselhorst and Seelig) and Department of Psychiatry (Drs. Ladewig, Müller–Spahn, and Seifritz, and K.M. Dürsteler–MacFarland), University of Basel, Switzerland; Psychiatric University Hospital (Dr. Stohler and K.M. Dürsteler–MacFarland), University of Zürich, Switzerland; Section of Medical Physics (Dr. Scheffler), Department of Radiology, University of Freiburg, Germany.

Address correspondence and reprint requests to Erich Seifritz, MD, Psychiatric University Hospital, Wilhelm Klein Str. 27, CH-4025 Basel, Switzerland; e-mail: Erich.Seifritz{at}unibas.ch

To examine possible metabolic frontal lobe alterations in IV heroin-dependent patients with different histories of concomitant substance use, N-acetylaspartate (NAA), a putative marker of neuronal viability, was measured by 1H-MRS. Compared with controls, NAA levels in patients were reduced by 7% in gray matter (p = 0.015) but not in white matter. To what extent comorbid conditions or substance use, including alcohol, contributed to these frontocortical metabolic changes remains to be elucidated.




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