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FADD: A link between TNF family receptors and caspases in Parkinson’s disease

From Institut National de la Santé et de la Recherche Médicale U 289, Hôpital de la Salpêtière, Paris, France.

Address correspondence and reprint requests to Dr. Etienne C. Hirsch, INSERM U 289, Hôpital de la Salpêtrière, 47 Boulevard de l’Hôpital, 75013 Paris, France; e-mail: hirsch{at}ccr.jussieu.fr

Fas-associating protein with a death domain (FADD) is a proximal adaptor protein of the tumor necrosis factor (TNF) receptor family death pathway. This human postmortem study showed a significant decrease in the percentage of FADD-immunoreactive dopaminergic (DA) neurons in the substantia nigra pars compacta of patients with PD compared with controls (-24.8%). This decrease correlated with the known selective vulnerability of nigral DA neurons in PD, suggesting that this pathway contributes to the susceptibility of DA neurons in PD to TNF-mediated apoptosis.

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