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Neurology 2002;58:317-320
© 2002 American Academy of Neurology
Brief Communications

MTR discloses subtle changes in the normal-appearing tissue from relatives of patients with MS

Malgorzata Siger–Zajdel, MD, Massimo Filippi, MD and Krzysztof Selmaj, MD PhD

From the Department of Neurology (Drs. Siger–Zajdel and Selmaj), Medical Academy of Lodz, Poland; and Neuroimaging Research Unit (Dr. Filippi), Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy.

Address correspondence and reprint requests to Prof. K. Selmaj, Department of Neurology, Medical Academy of Lodz, 22 Kopcinskiego Street, 90-153 Lodz, Poland; e-mail: kselmaj{at}afazja.am.lodz.pl

The presence of normal-appearing brain tissue (NABT) changes was investigated in 30 first-degree relatives of patients with MS, using magnetization transfer ratio (MTR) histograms. When compared with controls, relatives of patients with familial (p = 0.01) and sporadic (p = 0.01) MS had lower NABT MTR histogram peak heights. This study suggests a reduction of truly normal NABT in asymptomatic relatives of patients with MS.




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