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Neurology 2002;58:615-620
© 2002 American Academy of Neurology

Axonal multifocal motor neuropathy without conduction block or other features of demyelination

J.S. Katz, MD;, R.J. Barohn, MD;, S. Kojan, MD;, G.I. Wolfe, MD;, S.P. Nations, MD;, D.S. Saperstein, MD; and A.A. Amato, MD

From the Departments of Neurology, Palo Alto VA Medical Center and Stanford University (Dr. Katz), Palo Alto, CA; University of Kansas Medical Center (Dr. Barohn), Kansas City; University of Texas Southwestern Medical Center (Drs. Kojan, Wolfe, Nations, and Saperstein), Dallas; and Brigham and Women’s Hospital (Dr. Amato), Harvard Medical School, Boston, MA.

Address correspondence and reprint requests to Dr. Jonathan Katz, Department of Neurology (127), Department of Veterans Affairs, 3801 Miranda Ave., Palo Alto, CA 94304; e-mail: jskatz{at}stanford.edu

Background: Conduction block is considered an essential finding for the distinction between motor neuropathies and lower motor neuron disorders. Only a small number of reports describe patients with multifocal motor neuropathies who lack overt conduction block, although in these cases other features of demyelination still suggest the presence of a demyelinating disorder. In contrast, a purely axonal multifocal motor neuropathy has not been described.

Methods: This report describes nine patients with slowly or nonprogressive multifocal motor neuropathies who had purely axonal electrodiagnostic features.

Results: GM1 antibodies titers were normal in all nine cases. Six patients were treated with either prednisone or IV immunoglobulin and three showed convincing improvement.

Conclusions: These findings suggest an immune-mediated motor neuropathy with axonal electrophysiologic features that appears to be distinct from both multifocal motor neuropathy and established motor neuron disorders.




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Correspondence:

Read all Correspondence

Axonal multifocal motor neuropathy
Michael D Weiss
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Reply to Weiss
Jon S Katz, et al.
Neurology Online, 10 Jun 2002 [Full text]
Axonal multifocal motor neuropathy without conduction block or other features of demyelination
Daniel L. Menkes
Neurology Online, 6 Jun 2002 [Full text]
Axonal multifocal motor neuropathy without conduction block or other features of demyelination
Michael Donaghy, et al.
Neurology Online, 6 Jun 2002 [Full text]
Reply to both Letters to the Editor
Jonathan S. Katz, et al.
Neurology Online, 6 Jun 2002 [Full text]
Axonal multifocal motor neuropathy without conduction block or other features of demyelination
Ludovico Lispi, et al.
Neurology Online, 26 Sep 2002 [Full text]

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