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Neurology 2002;58:647-649
© 2002 American Academy of Neurology
Brief Communications

Serial MRI findings in a case of primary lateral sclerosis

Charles D. Smith, MD

From the Magnetic Resonance Imaging and Spectroscopy Center, and the Department of Neurology, University of Kentucky Medical Center, Lexington, KY.

Address correspondence and reprint requests to Dr. Charles Smith, 113 Davis-Mills Building, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536; e-mail: csmith{at}mri.uky.edu

A patient with primary lateral sclerosis (PLS) underwent MRI 3 times over 8.5 years. These images demonstrate progressive atrophy of the premotor, parietal, and primary sensorimotor cortex, with sparing of the temporal lobe, occipital lobe, and cerebellum. The pattern of cerebral atrophy was clearly restricted but was more extensive than expected from sensorimotor cortex pyramidal cell loss described in literature autopsy reports of PLS. Cortical motor system degeneration in PLS, whether primary or secondary, may be more extensive than previously believed.




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