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Neurology 2002;58:655-657
© 2002 American Academy of Neurology
Brief Communications

Diffusion abnormalities in patients with Wernicke encephalopathy

M. J. Doherty, MD;, N. F. Watson, MD;, K. Uchino, MD;, D. K. Hallam, MD; and S. C. Cramer, MD

From the Department of Neurology (Drs. Doherty, Watson, and Cramer), Department of Radiology (Dr. Hallam), University of Washington, Seattle; and Department of Neurology (Dr. Uchino), University of Texas at Houston.

Address correspondence and reprint requests to Dr. M.J. Doherty, Department of Neurology, University of Washington, Box 356465, Seattle, WA 98195; e-mail: mdoherty{at}u.washington.edu

Diffusion-weighted imaging (DWI) can help to diagnose acute ischemic stroke. Other nonischemic disorders may show abnormal signals with DWI. The authors report two cases of Wernicke encephalopathy with DWI signal changes in characteristic midline locations, one with reduction in apparent diffusion constant and one without. DWI abnormalities may suggest early thiamine deficiency and are useful in diagnosing Wernicke encephalopathy.




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