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Neurology 2002;58:658-660
© 2002 American Academy of Neurology
Brief Communications

Association and linkage of juvenile MS with HLA-DR2(15) in Russians

A. N. Boiko, MD;, E. I. Gusev, MD;, M. A. Sudomoina, PhD;, A. D. Alekseenkov, MSc;, O. G. Kulakova, PhD;, O. V. Bikova, MD;, O. I. Maslova, MD;, M. R. Guseva, MD;, S. Y. Boiko, MD;, M. E. Guseva, MD; and O. O. Favorova, PhD

From the Department of Neurology and Neurosurgery (Drs. A. Boiko, Gusev, M.R. Guseva, S. Boiko, and M.E. Guseva) and the Department of Molecular Biology and Medical Biotechnology (Drs. Sudomoina, Kulakova, Favorova, and Alekseenkov), Russian State Medical University, Moscow; and the Psychoneurological Department (Drs. Bikova and Maslova), Pediatric Institute of the Russian Academy of Medical Sciences, Moscow, Russia.

Address correspondence and reprint requests to Professor Olga Favorova, Department of Molecular Biology and Medical Biotechnology, RSMU, 3rd Cherepkovskaya ul., 15, Moscow, 121552 Russia; e-mail: Olga_Favorova{at}mail.ru

The aim of this study was to determine the role of the HLA-DRB1 gene [6p21] in susceptibility to juvenile MS (JMS) (age at onset <=15 years) of children of Russian descent. Association of DR2(15) with JMS has been found by the comparison of patients with JMS with both unrelated and affected family-based healthy controls. The linkage of DR2(15) with JMS was shown by transmission disequilibrium test. There were no significant differences in the frequencies of DRB1 alleles and genotypes between 56 patients with JMS and 234 patients with MS with age at onset >=16 years.




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