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Neurology 2002;58:814-816
© 2002 American Academy of Neurology
Brief Communications

Spontaneous CSF leaks: Underlying disorder of connective tissue

Bahram Mokri, MD, Cormac O. Maher, MD and Drahomira Sencakova, MD

From the Departments of Neurology (Dr. Mokri), Neurosurgery (Dr. Maher), and Radiology (Dr. Sencakova), Mayo Clinic, Rochester, MN.

Address correspondence and reprint requests to Dr. Bahram Mokri, Mayo Clinic, Department of Neurology, 200 First Street SW, Rochester, MN 55905; e-mail: bmokri{at}mayo.edu

Of 58 consecutive patients with spontaneous CSF leaks, nine exhibited features of connective tissue disorder. One had Marfan’s syndrome. Five additional patients had hyperflexible joints, of whom four had arachnodactyly, four were tall and slender, two had hyperextensible skin, and one had a strong family history of abdominal aorta aneurysms. Retinal detachment at a young age was noted in two. One patient had bilateral carotid dissections. A dural weakness may predispose patients to spontaneous CSF leak.




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