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Neurology 2002;58:821-823
© 2002 American Academy of Neurology
Brief Communications

1H MRSI predicts surgical outcome in MRI-negative temporal lobe epilepsy

J. Suhy, PhD, K.D. Laxer, MD, A.A. Capizzano, MD, P. Vermathen, PhD, G.B. Matson, PhD, N.M. Barbaro, MD and M.W. Weiner, MD

From the Departments of Radiology (Drs. Suhy, Capizzano, Vermathen, Matson, and Weiner), Neurology (Dr. Laxer), Medicine (Dr. Weiner), Psychiatry (Dr. Weiner), and Neurological Surgery (Dr. Barbaro), University of California, San Francisco; and Magnetic Resonance Unit (Drs. Suhy, Capizzano, Vermathen, Matson, and Weiner), DVA Medical Center, San Francisco, CA.

Address correspondence and reprint requests to Dr. Kenneth D. Laxer, Department of Neurology, University of California San Francisco, 400 Parnassus San Francisco, CA 94143-0138; e-mail laxer{at}itsa.ucsf.edu

1H MRS imaging (MRSI) was performed on 15 patients with MRI-negative temporal lobe epilepsy (TLE) who underwent seizure surgery. The non–seizure-free patients (NSF) ipsilateral hippocampal N-acetylaspartate (NAA)/(Cr+Cho) z scores were lower than the contralateral scores (p = 0.04), and the NSF ipsilateral z scores were lower than the seizure-free patients’ (SF) ipsilateral z scores (p = 0.0049). Similarly, NSF contralateral scores were lower than contralateral SF (p = 0.02). These findings suggest NAA predicts the surgical outcome in patients with TLE without evidence of mesial temporal sclerosis on MRI.




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