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From the Departments of Neurology (Drs. Wu, Garcia, Zhao, and Johnston, and D. Shek) and Pediatrics (Dr. Wu), University of California, San Francisco.
Address correspondence and reprint requests to Dr. Yvonne Wu, Department of Child Neurology, Box 0136, University of California, San Francisco, 500 Parnassus Avenue, Room 412, San Francisco, CA 94143-0136; e-mail: yvonne{at}itsa.ucsf.edu
Background: Few population-based studies of status epilepticus have been performed in the United States.
Objective: To determine the incidence, case fatality, and demographics of generalized convulsive status epilepticus (GCSE) in the state of California.
Methods: Using a state-wide hospital discharge database, the authors identified all hospitalizations from 1991 through 1998 with a discharge diagnosis of convulsive status epilepticus. They identified the first admission for each individual to estimate the incidence of GCSE. In-hospital case fatality rates were calculated, and multivariate analysis was performed to determine predictors of death during hospitalization. Secondary diagnoses were analyzed by retrieving all discharge diagnoses accompanying the diagnosis of GCSE.
Results: The incidence rate of GCSE was 6.2/100,000 population and fell by 42% between the years 1991 and 1998 from 8.5 to 4.9/100,000. The rate of GCSE was highest among children under the age of 5 (7.5/100,000) and among the elderly (22.3/100,000). Blacks also demonstrated a relatively high incidence of GCSE (13.4/100,000). The case fatality for incident admissions was 10.7%, with increasing age being the only significant predictor in multivariate analysis. Case fatality was highest in patients who also carried a diagnosis of anoxia, CNS infection, or stroke.
Conclusions: The incidence of GCSE requiring hospitalization has fallen over the last decade and is lower than that reported in previous studies. The case fatality is also lower than that reported previously. Further studies are needed to determine the cause of this decline in incidence and mortality of GCSE.
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