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Neurology 2002;58:1125-1128
© 2002 American Academy of Neurology
Brief Communications

Interleukin-2 in the pathogenesis of perinatal white matter damage

H. Kadhim, MD PhD, B. Tabarki, MD, C. De Prez, MD, A.-M. Rona and G. Sébire, MD PhD

From the Laboratoire de Neurologie du Développement (Drs. Kadhim, Tabarki, and Sébire, and A.-M. Rona), Université Catholique de Louvain (U.C.L), and Unité de Neuropathologie (Drs. Kadhim and De Prez), Service d’Anatomopathologie, CHU Brugmann-HUDERF (U.L.B), Brussels, Belgium.

Address correspondence and reprint requests to Dr. Hazim Kadhim, Laboratoire de Neurologie du Développement, Université Catholique de Louvain (U.C.L), Ave. E. Mounier 52, Tour Vésale, NEPE, 1200 Brussels, Belgium; e-mail: Hazim.Kadhim{at}nepe.ucl.ac.be

Proinflammatory cytokines were reported to be implicated in the pathogenesis of perinatal white matter lesions. The authors document for the first time the in situ detection of interleukin-2 and interleukin-2 receptor (IL-2R) in these human white matter lesions. These results suggest that interleukin-2, reported to be toxic to oligodendrocytes and myelin, could play a role in the molecular cascade leading to white matter damage in periventricular leukomalacia.




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