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From the Departments of Neurology (Drs. Schwid, Goodman, and McDermott) and Biostatistics (Dr. McDermott), University of Rochester Medical Center, NY; Department of Neurology (Dr. Bever), University of Maryland, Baltimore; and Department of Neurology (Dr. Cook), University of Medicine and Dentistry of New Jersey, Newark.
Address correspondence and reprint requests to Dr. Steven R. Schwid, 601 Elmwood Ave., Box 605, Rochester, NY 14642; e-mail: Steven_Schwid{at}urmc.rochester.edu
As a first step toward understanding which changes should be considered as meaningful, the authors assessed the reliability of quantitative functional tests on 5 consecutive days in 63 patients with MS, determining the range of measurement variability present when patients are clinically stable. Time to walk 25 feet (T25FW) and the 9-hole peg test (9HPT) varied by <20% of individual mean scores on repeated testing. Therefore, a 20% change on these tests can be considered to be the threshold that reliably indicates a true change in function for an individual.
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