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Neurology 2002;58:1297-1299
© 2002 American Academy of Neurology
Brief Communications

Anterior commissure absence without callosal agenesis: A new brain malformation

T. N. Mitchell, MRCP, J. M. Stevens, FRACR, S. L. Free, PhD, J. W. Sander, MRCP PhD, S. D. Shorvon, MD FRCP and S. M. Sisodiya, MRCP PhD

From the Department of Clinical and Experimental Epilepsy (Drs. Mitchell, Free, Sander, Shorvon, and Sisodiya), and Division of Neuroradiology (Dr. Stevens), Institute of Neurology, University College London, and National Society for Epilepsy, Chalfont-St-Peter, UK.

Address correspondence and reprint requests to Dr. S.M. Sisodiya, Epilepsy Research Group, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK; e-mail: sisodiya{at}ion.ucl.ac.uk

The authors report a novel human brain malformation characterized by the absence of the anterior commissure without callosal agenesis, but associated with gross unilateral panhemispheric malformation incorporating subependymal heterotopia, subcortical heterotopia, and gyral abnormalities including temporal malformation and polymicrogyria. In contrast, a normal anterior commissure was found in 125 control subjects and in 113 other subjects with a range of brain malformations.




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P. J. Thompson, T. N. Mitchell, S. L. Free, K. A. Williamson, I. M. Hanson, V. van Heyningen, A. T. Moore, and S. M. Sisodiya
Cognitive functioning in humans with mutations of the PAX6 gene
Neurology, April 13, 2004; 62(7): 1216 - 1218.
[Abstract] [Full Text] [PDF]


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