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Neurology 2002;58:1418-1422
© 2002 American Academy of Neurology
Brief Communications

Gender and pramipexole effects on levodopa pharmacokinetics and pharmacodynamics

K. Kompoliti, MD, C. H. Adler, MD PhD, R. Raman, MS, J. H. Pincus, MD, M. T. Leibowitz, MD, J. J. Ferry, PhD, L. Blasucci, RN CCRC, J. N. Caviness, MD, S. Leurgans, PhD, W. M. Chase, BS MT(ASCP), L. C. Yones, BS RN, CCRC, E. Tan, BS CCRC, P. Carvey, PhD and C. G. Goetz, MD

From the Rush–Presbyterian–St Luke’s Medical Center (Drs. Kompoliti, Leurgans, Carvey, and Goetz, R. Raman and L. Blasucci), Chicago, IL; Mayo Clinic Scottsdale (Drs. Adler and Caviness), AZ; Georgetown University (Dr. Pincus), Washington, DC; California Clinical Trials Medical Group (Dr. Leibowitz, L.C. Yones and E. Tan), Beverly Hills; and Pharmacia Corporation (Dr. Ferry, W.M. Chase), Kalamazoo, MI.

Address correspondence and reprint requests to Dr. Katie Kompoliti, Section of Movement Disorders, Department of Neurological Science, 1725 W. Harrison St., Suite 755, Chicago, IL 60612; e-mail: kkompoli{at}rush.edu

The authors studied the pharmacokinetics of levodopa (LD) with and without pramipexole (PPX) in men and postmenopausal women with PD. Patients on stable dose of carbidopa/LD were randomized to receive escalating doses of placebo or PPX over 7 weeks. LD and PPX pharmacokinetics were performed after a single test dose 25/100 of carbidopa/LD, before initiation of PPX or placebo, at 1.5 mg/d and 4.5 mg/d of PPX or placebo. Compared to men, women had greater LD bioavailability. PPX did not alter LD bioavailability, and PPX pharmacokinetics were equivalent in men and women.




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Correspondence:

Read all Correspondence

Gender and pramipexole effects on levodopa pharmacokinetics and pharmacodynamics
Aldo Quattrone, et al.
Neurology Online, 16 Aug 2002 [Full text]
Reply to Letter to the Editor
Katie Kompoliti
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