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Linkage analysis of Alzheimer disease with psychosis

From the Departments of Psychiatry (Drs. Bacanu, Devlin, Chowdari, DeKosky, Nimgaonkar, and Sweet) and Neurology (Dr. DeKosky), University of Pittsburgh, School of Medicine, PA.

Address correspondence and reprint requests to Robert A. Sweet, MD, Department of Psychiatry, University of Pittsburgh Medical Center, 3811 O’Hara Street, Pittsburgh, PA 15213; e-mail:sweetra{at}msx.upmc.edu

Although a portion of risk for late-onset AD (LOAD) is attributable to APOE, the search for other loci is ongoing. The authors hypothesize that psychotic symptoms with LOAD (LOAD+P) identify a potentially more etiologically homogeneous form of AD. Linkage analysis of families with LOAD+P identified one significant and several suggestive novel linkage signals, which bolsters the conjecture of greater etiologic homogeneity.

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