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Donepezil and flight simulator performance: Effects on retention of complex skills

From the Palo Alto Veterans Affairs Health Care System (Drs. Yesavage, Taylor, Sheikh, and Tinklenberg); Department of Psychiatry and Behavioral Sciences (Drs. Yesavage, Mumenthaler, Taylor, Friedman, O’Hara, Sheikh, and Tinklenberg), Stanford University School of Medicine, CA; and Departments of Neurology, Psychiatry, Neuroscience, Psychology, Nursing, Organizational Behavior, and Biomedical Ethics (Dr. Whitehouse), Case Western Reserve University, Cleveland, OH.

Address correspondence and reprint requests to Dr. Jerome Yesavage, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305-5550; e-mail: yesavage{at}stanford.edu

We report a randomized, double-blind, parallel group, placebo-controlled study to test the effects of the acetylcholinesterase inhibitor, donepezil (5 mg/d for 30 days), on aircraft pilot performance in 18 licensed pilots with mean age of 52 years. After 30 days of treatment, the donepezil group showed greater ability to retain the capacity to perform a set of complex simulator tasks than the placebo group, p < 0.05. Donepezil appears to have beneficial effects on retention of training on complex aviation tasks in nondemented older adults.

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