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Neurology 2002;59:126-128
© 2002 American Academy of Neurology
Brief Communications

Normal-appearing brain tissue MTR histograms in clinically isolated syndromes suggestive of MS

A. Traboulsee, FRCPC, J. Dehmeshki, PhD, P. A. Brex, MRCP, C. M. Dalton, MRCPI, D. Chard, MRCP, G. J. Barker, PhD, G. T. Plant, FRCP and D. H. Miller, FRCP

From the NMR Research Unit, Institute of Neurology, University College London, United Kingdom.

Address correspondence and reprint requests to Prof. DH Miller, NMR Research Unit, Department of Clinical Neurology, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK; e-mail: d.miller{at}ion.ucl.ac.uk

Segmented normal-appearing brain tissue (NABT) was investigated in 40 patients with a recent onset and 13 patients with a remote onset of a clinically isolated syndrome (CIS) using magnetization transfer ratio (MTR) histograms. Abnormalities were present in patients with a high risk for MS (recent onset and T2-weighted lesions present) and in those with a low risk for relapse (recent onset without T2-weighted lesions). Similar mild NABT abnormality was present with CIS and no further disease activity 14 years later. NABT MTR abnormality in CIS may indicate susceptibility to demyelination but not to disease progression.




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