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Worsening of multifocal motor neuropathy during pregnancy

From the Department of Neurology (Drs. Chaudhry and Cornblath), Johns Hopkins University School of Medicine, Baltimore, MD; and Department of Neurology (Dr. Escolar), Children’s National Medical Center, Washington, DC.

Address correspondence and reprint requests to Dr. Chaudhry, Johns Hopkins Outpatient Center, 5072 A, 600 North Caroline Street, Baltimore, MD 21287; e-mail: vchaudh{at}jhmi.edu

Three women with multifocal motor neuropathy (MMN) were treated during pregnancy. Compared with their pregestation strength, the women became weaker in previously involved muscles and showed new weakness in previously unaffected muscles. All were treated with IV immunoglobulin during pregnancy and improved in strength. After pregnancy, strength in all patients returned to the prepregnancy state. The authors conclude that pregnancy may worsen MMN.

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