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Neurology 2002;59:1622-1624
© 2002 American Academy of Neurology
Brief Communications

Relationship between CAG repeat length and late-stage outcomes in Huntington’s disease

K. Marder, MD MPH, S. Sandler, MS RD, A. Lechich, MD, J. Klager, MD and S.M. Albert, PhD MSc

From the Department of Neurology, Sergievsky Center, and The Taub Institute, Columbia University (Drs. Marder and Albert); Terence Cardinal Cooke Health Care Center, New York Medical College (Drs. Lechich and Klager and S. Sandler); and Mailman School of Public Health, Columbia University (Dr. Albert), New York, NY.

Address correspondence and reprint requests to Dr. Karen Marder, Sergievsky Center, PH19 Room 303, 630 West 168th St., New York, NY 10032; e-mail ksm1{at}columbia.edu

The relationship between CAG repeat length and age at nursing home (NH) admission and age at percutaneous endoscopic gastrostomy (PEG) was examined in 47 residents of a specialized Huntington’s disease long-term care facility who were observed for a median of 3 years (range, 1 to 11 years). CAG repeat length was inversely correlated with time to NH admission and PEG (both p < 0.001), independent of age at onset. CAG repeat length may influence disease progression to late-stage outcomes in addition to age at onset.






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