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MMP-9 correlates with electrophysiologic abnormalities in Guillain–Barré syndrome

To investigate the role of MMP-9 in Guillain-Barré syndrome, the authors correlated electrophysiologic abnormalities and MMP-9 plasma levels in a series of 21 patients. MMP-9 plasma levels were higher in the demyelinating group than in the nondemyelinating group, and in patients with high CSF protein level. Increase of MMP-9 circulating levels correlated with the increase of F waves latencies, reduction of CMAP amplitude, and decrease of nerve conduction velocities. Circulating MMP-9 may contribute to the peripheral nerve dysfunction of demyelinating Guillain-Barré syndrome.

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				J-P Lefaucheur and A Creange Neurophysiological testing correlates with clinical examination according to fibre type involvement and severity in sensory neuropathy J. Neurol. Neurosurg. Psychiatry, March 1, 2004; 75(3): 417 - 422. [Abstract] [Full Text] [PDF]