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Neurology 2002;59:1652-1655
© 2002 American Academy of Neurology
Brief Communications

The chemokine receptor CCR5 deletion mutation is associated with MS in HLA-DR4–positive Russians

O. O. Favorova, PhD, T. V. Andreewski, MSc, A. N. Boiko, MD, M. A. Sudomoina, PhD, A. D. Alekseenkov, MSc, O. G. Kulakova, PhD, A. V. Slanova, MSc and E. I. Gusev, MD

From the Department of Neurology and Neurosurgery (Drs. Boiko, Slanova, and Gusev) and Department of Molecular Biology and Medical Biotechnology (Drs. Favorova, Andreewski, Sudomoina, Alekseenkov, and Kulakova), Russian State Medical University, Moscow, Russia.

Address correspondence and reprint requests to Prof. Olga Favorova, Department of Molecular Biology and Medical Biotechnology, RSMU, 3rd Cherepkovskaya ul., 15, Moscow, 121552 Russia; e-mail: olga_favorova{at}mail.ru

The authors studied the possible association between the presence of a 32-base pair deletion allele in CC chemokine receptor 5 gene [3p21] (CCR5{Delta}32 allele) and the occurrence of MS. The presence of CCR5{Delta}32 homozygotes among patients with MS indicates that the absence of CCR5 did not protect against MS. Moreover, the CCR5{Delta}32 mutation was associated with MS in HLA-DR4–positive Russians (pcorr < 0.001, odds ratio [OR] = 25.0). The (CCR5{Delta}32,DR4)-positive phenotype was negatively associated with early MS onset (at ages <=18 years) (p = 0.0115, OR = 0.1).




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