| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Institute for Ageing and Health (Drs. Ballard, McKeith, O’Brien, Gray, Burn, and Tovee, and F. Cormack and T. Cassidy), University of Newcastle, UK; Rogaland Psykiatriske Sjukehus (Drs. Aarsland and Larsen, and R. Starfeldt), Stavanger, Norway; and Institute of Psychiatry (Dr. Brown), London, UK.
Address correspondence and reprint requests to Dr. C.G. Ballard, Wolfson Research Centre, Newcastle General Hospital, Westgate Rd., Newcastle upon Tyne, NE4 6BE UK; e-mail: c.g.ballard{at}ncl.ac.uk
Background: Marked impairments in and fluctuation of attention are characteristic of dementia with Lewy bodies (DLB). The comparative impairment of these cognitive domains in PD and PD dementia (PD dementia) has not been studied, and is important to the conceptual understanding of parkinsonian dementias.
Method: Detailed evaluations of attention and fluctuating attention (Cognitive Drug Research computerized battery) were undertaken in 278 subjects (50 DLB, 48 PD dementia, 50 PD, 80 AD, 50 elderly controls) from the Newcastle dementia register and the Stavanger PD register (controls, PD, and PD dementia patients were recruited from both centers). DLB, AD, PD, and PD dementia were diagnosed using operationalized criteria.
Results: Impairments in reaction time, vigilance, and fluctuating attention were comparable in patients with DLB and PD dementia, but were less substantially impaired in patients with DLB without parkinsonism. Patients with PD had significantly greater impairment of cognitive reaction time than elderly controls, and comparable impairments of cognitive reaction time to patients with AD. Patients with PD, however, did not exhibit fluctuation of attention.
Conclusion: The profile of attentional impairments and fluctuating attention is similar in PD dementia and DLB with parkinsonism. The current findings do not support the current arbitrary distinctions between these patient groups. Importantly, patients with PD do not experience fluctuating attention.
This article has been cited by other articles:
|
|
 |
|
  L. Bonanni, A. Thomas, P. Tiraboschi, B. Perfetti, S. Varanese, and M. Onofrj EEG comparisons in early Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease with dementia patients with a 2-year follow-up Brain, March 1, 2008; 131(3): 690 - 705. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Levy and G. J. Chelune Cognitive-Behavioral Profiles of Neurodegenerative Dementias: Beyond Alzheimer's Disease J Geriatr Psychiatry Neurol, December 1, 2007; 20(4): 227 - 238. [Abstract] [PDF]
|
|
|
|
 |
|
 K Mondon, A Gochard, A Marque, A Armand, D Beauchamp, C Prunier, D Jacobi, B de Toffol, A Autret, V Camus, et al. Visual recognition memory differentiates dementia with Lewy bodies and Parkinson's disease dementia J. Neurol. Neurosurg. Psychiatry, July 1, 2007; 78(7): 738 - 741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S A Molloy, E N Rowan, J T O'Brien, I G McKeith, K Wesnes, and D J Burn Effect of levodopa on cognitive function in Parkinson's disease with and without dementia and dementia with Lewy bodies J. Neurol. Neurosurg. Psychiatry, December 1, 2006; 77(12): 1323 - 1328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J M Bradshaw, M Saling, V Anderson, M Hopwood, and A Brodtmann Higher cortical deficits influence attentional processing in dementia with Lewy bodies, relative to patients with dementia of the Alzheimer's type and controls J. Neurol. Neurosurg. Psychiatry, October 1, 2006; 77(10): 1129 - 1135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K Bronnick, U Ehrt, M Emre, P P De Deyn, K Wesnes, S Tekin, and D Aarsland Attentional deficits affect activities of daily living in dementia-associated with Parkinson's disease J. Neurol. Neurosurg. Psychiatry, October 1, 2006; 77(10): 1136 - 1142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. P. Mosimann, E. N. Rowan, C. E. Partington, D. Collerton, E. Littlewood, J. T. O'Brien, D. J. Burn, and I. G. McKeith Characteristics of Visual Hallucinations in Parkinson Disease Dementia and Dementia With Lewy Bodies Am J Geriatr Psychiatry, February 1, 2006; 14(2): 153 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. G. McKeith, D. W. Dickson, J. Lowe, M. Emre, J. T. O'Brien, H. Feldman, J. Cummings, J. E. Duda, C. Lippa, E. K. Perry, et al. Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium Neurology, December 27, 2005; 65(12): 1863 - 1872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Wesnes, I. McKeith, C. Edgar, M. Emre, and R. Lane Benefits of rivastigmine on attention in dementia associated with Parkinson disease Neurology, November 22, 2005; 65(10): 1654 - 1656. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zaccai, C. McCracken, and C. Brayne A systematic review of prevalence and incidence studies of dementia with Lewy bodies Age Ageing, November 1, 2005; 34(6): 561 - 566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. P. Mosimann, R. M. Muri, D. J. Burn, J. Felblinger, J. T. O'Brien, and I. G. McKeith Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies Brain, June 1, 2005; 128(6): 1267 - 1276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. P. Mosimann, G. Mather, K. A. Wesnes, J. T. O'Brien, D. J. Burn, and I. G. McKeith Visual perception in Parkinson disease dementia and dementia with Lewy bodies Neurology, December 14, 2004; 63(11): 2091 - 2096. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Santamaria How to evaluate excessive daytime sleepiness in Parkinson's disease Neurology, October 26, 2004; 63(8_suppl_3): S21 - S23. [Abstract] [Full Text]
|
|
|
|
|
|
C. Serrano and D. Garcia-Borreguero Fluctuations in cognition and alertness in Parkinson's disease and dementia Neurology, October 26, 2004; 63(8_suppl_3): S31 - S34. [Abstract] [Full Text]
|
|
|
|
|
|
J. L. Cummings Dementia with Lewy Bodies: Molecular Pathogenesis and Implications for Classification J Geriatr Psychiatry Neurol, September 1, 2004; 17(3): 112 - 119. [Abstract] [PDF]
|
|
|
|
|
|
D. Aarsland, C. G. Ballard, and G. Halliday Are Parkinson's Disease with dementia and Dementia with lewy Bodies the Same Entity? J Geriatr Psychiatry Neurol, September 1, 2004; 17(3): 137 - 145. [Abstract] [PDF]
|
|
|
|
|
|
E. J. Burton, I. G. McKeith, D. J. Burn, E. D. Williams, and J. T. O'Brien Cerebral atrophy in Parkinson's disease with and without dementia: a comparison with Alzheimer's disease, dementia with Lewy bodies and controls Brain, April 1, 2004; 127(4): 791 - 800. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Bradshaw, M Saling, M Hopwood, V Anderson, and A Brodtmann Fluctuating cognition in dementia with Lewy bodies and Alzheimer's disease is qualitatively distinct J. Neurol. Neurosurg. Psychiatry, March 1, 2004; 75(3): 382 - 387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Foltynie, C. E. G. Brayne, T. W. Robbins, and R. A. Barker The cognitive ability of an incident cohort of Parkinson's patients in the UK. The CamPaIGN study Brain, March 1, 2004; 127(3): 550 - 560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Ferman, G. E. Smith, B. F. Boeve, R. J. Ivnik, R. C. Petersen, D. Knopman, N. Graff-Radford, J. Parisi, and D. W. Dickson DLB fluctuations: Specific features that reliably differentiate DLB from AD and normal aging Neurology, January 27, 2004; 62(2): 181 - 187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D Aarsland, I Litvan, D Salmon, D Galasko, T Wentzel-Larsen, and J P Larsen Performance on the dementia rating scale in Parkinson's disease with dementia and dementia with Lewy bodies: comparison with progressive supranuclear palsy and Alzheimer's disease J. Neurol. Neurosurg. Psychiatry, September 1, 2003; 74(9): 1215 - 1220. [Abstract] [Full Text] [PDF]
|
|
Read all Correspondence
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
