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 Volume 59, Number 11, December 10, 2002
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Neurology 2002;59:1773-1775
© 2002 American Academy of Neurology
Brief Communications

Seronegative Lambert-Eaton myasthenic syndrome

Study of 110 Japanese patients

Y.K. Nakao, MD, M. Motomura, MD, T. Fukudome, MD, T. Fukuda, MD, H. Shiraishi, MD, T. Yoshimura, MD, M. Tsujihata, MD and K. Eguchi, MD

From the First Department of Internal Medicine (Drs. Nakao, Motomura, Fukuda, Shiraishi, and Eguchi), Nagasaki University School of Medicine; Department of Neurology (Dr. Fukudome), Kawatana National Hospital; School of Health Sciences (Dr. Yoshimura), Nagasaki University; and Division of Neurology (Dr. Tsujihata), Nagasaki Kita Hospital, Japan.

Address correspondence and reprint requests to Dr. Katsumi Eguchi, the First Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan; e-mail: eguchi{at}net.nagasaki-u.ac.jp

The authors characterized the clinical and immunologic features of 110 patients with Lambert-Eaton myasthenic syndrome (LEMS). Anti-P/Q-type voltage-gated calcium channels (VGCC) antibodies were detected in 85% of the patients (seropositive) but not in the rest (seronegative). Except for the indication that small cell lung carcinoma is less common in seronegative patients, no significant differences were found in the clinical characteristics of patients who had or did not have anti-P/Q-type VGCC antibodies. The results of passive transfer experiments suggest that seronegative LEMS is also an autoantibody-mediated disorder.




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