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Neurology 2002;59:1789-1791
© 2002 American Academy of Neurology
Brief Communications

Repetitive transcranial magnetic stimulation for Tourette syndrome

A. Münchau, MD, B.R. Bloem, PhD, K.V. Thilo, PhD, M.R. Trimble, MD, J.C. Rothwell, PhD and M.M. Robertson, MD

From the Sobell Department of Neurophysiology (Drs. Münchau, Bloem, Thilo, and Rothwell) and Department of Clinical Neurology (Drs. Münchau, Trimble, and Robertson), Institute of Neurology, National Hospital for Neurology and Neurosurgery, University College London, Queen Square, UK.

Address correspondence and reprint requests to Prof. Mary M. Robertson, Department of Clinical Neurology, Institute of Neurology, Queen Square, London WC1N 3BG, UK; e-mail: Profmmr{at}aol.com

In a single-blinded, placebo-controlled, crossover repetitive transcranial magnetic stimulation (rTMS) trial, 16 patients with Gilles de la Tourette syndrome (GTS) received in random sequence 1 Hz motor, premotor, and sham rTMS, which each consisted of two 20-minute rTMS sessions applied on 2 consecutive days. In the 12 patients who completed the trial, there was no significant improvement of symptoms after any of the rTMS conditions as assessed with the Motor tic, Obsessions and compulsions, Vocal tic Evaluation Survey.




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