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Impaired renal function in progressive multiple sclerosis

From the Department of Neurology (Dr. Calabresi), University of Maryland School of Medicine, Baltimore; National Institutes of Health (Drs. Austin, Choyke, and McFarland, and H. Maloni), Bethesda, MD; Department of Neurology (Dr. Racke), University of Texas, Southwestern Medical School, Dallas; and Department of Neurology (Dr. Goodman), University of Rochester School of Medicine, Rochester, NY.

Address correspondence and reprint requests to Dr. P.A. Calabresi, Department of Neurology, University of Maryland School of Medicine, 655 W. Baltimore St., Room 12-027, Baltimore, MD 21201; e-mail: pcala001{at}Umaryland.edu

The authors analyzed renal function in 25 patients with progressive MS. The mean glomerular filtration rate (GFR) was 92 mL/min/1.73 m², compared to the predicted GFR of 110 (p < 0.001). Nine of the 25 (36%) patients had abnormally low GFR (<90). The mean serum creatinine for patients with MS was lower than predicted normal values and poorly estimated GFR using standard equations. These data document impaired renal function in patients with progressive MS and have implications for treatment of these patients with potentially nephrotoxic drugs.

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