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Neurology 2002;59:1804-1807
© 2002 American Academy of Neurology
Brief Communications

Identification of a susceptibility locus for migraine with and without aura on 6p12.2-p21.1

A. Carlsson, MSc, L. Forsgren, MD PhD, P.-O. Nylander, MD PhD, U. Hellman, MSc, K. Forsman-Semb, PhD, G. Holmgren, MD PhD, D. Holmberg, PhD and M. Holmberg, PhD

From Umeå Centre for Molecular Medicine (A. Carlsson and Dr. D. Holmberg) and the Departments of Neurology (Dr. Forsgren), Medical Bioscience/Clinical Genetics (U. Hellman and Drs. Forsman-Semb and Holmgren), and Molecular Biology (Dr. M. Holmberg), University of Umeå; and Department of Neuroscience and Locomotion, University of Linköping, and Department of Psychiatry (Dr. Nylander), Kalmar Hospital, Sweden.

Address correspondence and reprint requests to Dr. Monica Holmberg, Department of Molecular Biology, Umeå University, S-901 87 Umeå, Sweden; e-mail: monica.holmberg{at}molbiol.umu.se

Migraine is the most common type of chronic episodic headache. To find novel susceptibility genes for familial migraine with and without aura, a genomewide screen was performed in a large family from northern Sweden. Evidence of linkage was obtained on chromosome 6p12.2-p21.1, with a maximum two-point lod score of 5.41 for marker D6S452. The patients with migraine shared a common haplotype of 10 Mb between markers D6S1650 and D6S1960.




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[Abstract] [Full Text] [PDF]


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