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Neurology 2002;59:1971-1973
© 2002 American Academy of Neurology
Brief Communications

Improvement of diabetic autonomic gustatory sweating by botulinum toxin type A

D.A. Restivo, MD PhD, S. Lanza, MD, F. Patti, MD, S. Giuffrida, MD, R. Marchese-Ragona, MD, P. Bramanti, MD and A. Palmeri, MD PhD

From the Departments of Physiological Sciences (Drs. Restivo and Palmeri) and Neurological Sciences (Drs. Patti and Giuffrida), University of Catania; Centro per lo studio ed il trattamento dei neurolesi lungodegenti (Drs. Restivo and Bramanti), University of Messina; Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS) (Dr. Lanza), Troina; and ENT Department (Dr. Marchese-Ragona), University of Padova, Italy.

Address correspondence and reprint requests to Dr. Agostino Palmeri, Dipartimento di Scienze Fisiologiche, University of Catania, Viale A. Doria, 6, 95125 Catania, Italy; e-mail: apalmeri{at}mbox.unict.it

Fourteen diabetic subjects with gustatory sweating were treated by intracutaneous injections of botulinum toxin type A into the affected facial skin areas. In all subjects, sweating (measured by Minor starch iodine test) ceased within 4 days, with the maximal follow-up time lasting 24 weeks. This therapeutic approach, which could be used to reduce the severity of diabetic gustatory sweating, appears to be long lasting, adverse effect free, and minimally invasive.