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Neurology 2002;59:1982-1984
© 2002 American Academy of Neurology
Brief Communications

Minimal tissue damage after stimulation of the motor thalamus in a case of chorea-acanthocytosis

P. Burbaud, MD PhD, A. Vital, MD PhD, A. Rougier, MD, S. Bouillot, MD, D. Guehl, MD PhD, E. Cuny, MD, X. Ferrer, MD, A. Lagueny, MD and B. Bioulac, MD PhD

From the Departments of Clinical Neurophysiology (Drs. Burbaud, Guehl, and Bioulac), Neuropathology Laboratory (Drs. Vital and Bouillot), Neurology (Drs. Ferrer and Lagueny), and Neurosurgery (Drs. Cuny and Rougier), Hôpital Pellegrin, Bordeaux, France.

Address correspondence and reprint requests to Dr. Pierre Burbaud, Service d’Explorations Fonctionnelles du Système Nerveux (2è étage), Hôpital Pellegrin, Place Amélie Rabat-Léon, 33076 Bordeaux, France; e-mail: Pierre.Burbaud{at}umr5543.u-bordeaux2.fr

Autopsy findings are reported from a patient with chorea-acanthocytosis treated for 2 years by deep brain stimulation (DBS) of the motor thalamus. Postoperative testing showed a progressive improvement in axial truncal spasms. Although relatively high currents were used for 2 years in this patient, postmortem analysis showed minimal tissue damage in the vicinity of the electrode tip. It is concluded that DBS has little impact on the surrounding tissues.




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R. H. Walker, H. H. Jung, C. Dobson-Stone, L. Rampoldi, A. Sano, F. Tison, and A. Danek
Neurologic phenotypes associated with acanthocytosis
Neurology, January 9, 2007; 68(2): 92 - 98.
[Abstract] [Full Text] [PDF]


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