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Neurology 2002;59:1988-1991
© 2002 American Academy of Neurology
Brief Communications

Corticospinal excitability in human sleep as assessed by transcranial magnetic stimulation

P. Grosse, MD*, R. Khatami, MD*, F. Salih, MD, A. Kühn, MD and B.-U. Meyer, MD{dagger}

*According to their contribution to the study, both authors act equally as principal authors.
{dagger}Deceased November 24, 2001.
From the Neurologische Klinik und Poliklinik, Charité, Campus Virchow-Klinikum, Berlin, Germany.

Address correspondence and reprint requests to Dr. Pascal Grosse, Sobell Department of Clinical Neurophysiology (Box 146), Institute of Neurology, 8-11 Queen Square, London WC1N 3BG, UK; e-mail: p.grosse{at}ion.ucl.ac.uk

The excitability of the corticospinal system was studied in 23 healthy subjects in sleep stages NREM2, NREM4, REM, and wakefulness using transcranial magnetic stimulation. Assessment of motor thresholds, stimulus-response curves, and latencies of motor evoked potentials shows activation of the fast-conducting corticospinal fibers in all sleep stages and a neuronal recruitment pattern similar to wakefulness, however, at a lower level of excitability and with significant differences between sleep stages.




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