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Neurology 2002;59:1994-1997
© 2002 American Academy of Neurology
Brief Communications

CNS angiitis in graft vs host disease

M. Ma, MD PhD*, G. Barnes, MD PhD*, J. Pulliam, MD, D. Jezek, MS, R. J. Baumann, MD and J. R. Berger, MD

*These authors contributed equally to this work.
From the Departments of Neurology (Drs. Ma, Barnes, Baumann, and Berger), Pathology (Dr. Pulliam, D. Jezek), and Pediatrics (Drs. Barnes and Baumann), University of Kentucky College of Medicine, Lexington, KY.

Address correspondence and reprint requests to Dr. Gregory Barnes, Department of Neurology, University of Kentucky College of Medicine, L445, Wing D, Kentucky Clinic, 704 South Limestone, Lexington, KY 40536; e-mail: gnbarn2{at}pop.uky.edu

Graft-vs-host disease (GVHD) is a potentially treatable cause of progressive neurologic decline after bone marrow transplantation (BMT). The authors present histologic confirmation of CNS granulomatous angiitis in a child with chronic GVHD after BMT. Since cranial MRI showed only nonspecific findings, CNS vasculitis associated with GVHD after BMT may be underdiagnosed.




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