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Neurology 2002;59:1998-2001
© 2002 American Academy of Neurology
Brief Communications

Similar binding to glutamate receptors by Rasmussen and partial epilepsy patients’ sera

P. Bernasconi, PhD, B. Cipelletti, PhD, L. Passerini, PhD, T. Granata, MD, C. Antozzi, MD, R. Mantegazza, MD and R. Spreafico, MD PhD

From the Immunology and Muscular Pathology Unit (Drs. Bernasconi, Passerini, and Mantegazza) and Departments of Experimental Neurophysiology and Epilepsy (Drs. Cipelletti and Spreafico), Child Neurology (Dr. Granata), and Neuromuscular Diseases (Dr. Antozzi), Istituto Nazionale Neurologico "Carlo Besta," Milan, Italy.

Address correspondence and reprint requests to Dr. Roberto Spreafico, Department of Experimental Neurophysiology and Epilepsy, Istituto Nazionale Neurologico "Carlo Besta," Via Celoria 11, 20133 Milan, Italy; e-mail: spreafico{at}istituto-besta.it

Immunoreactivity of sera from patients with Rasmussen encephalitis (RE) and patients with partial epilepsy (PE) was analyzed by immunohistoblot on rat brain sections and the staining pattern compared with that obtained with antibodies to a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid and NMDA receptors. Staining for anti-glutamate receptor 3 (GluR3) was found in 82% of patients with RE and 64% of patients with PE. Histoblot analysis showed a positive staining in GluR3- and NMDA-specific regions of rat brain, providing a comprehensive CNS immunolocalization.




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