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Total intracranial volume: Normative values and lack of association with Alzheimer’s disease

From the Departments of Health Sciences Research (Drs. Edland, O’Brien, Petersen, and M. Plevak), Neurology (Dr. Petersen), Internal Medicine (Dr. Tangalos), and Radiology (Drs. Xu and Jack), Mayo Clinic and Mayo Foundation, Rochester, MN.

Address correspondence and reprint requests to Dr. S.D. Edland, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905; e-mail: edland.steven{at}mayo.edu

A larger premorbid brain is hypothesized to provide neuronal reserve against AD. Using MRI data from ongoing studies of normal aging and AD, the authors tested this hypothesis. Mean total intracranial volume was 15.8 cm³ smaller for cases among women (n = 121 normal and 104 AD; p = 0.24) and 10.1 cm³ larger for cases among men (n = 63 normal and 62 AD; p = 0.59). These differences are small and nonsignificant, suggesting that head size per se is not a critical determinant of AD.

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