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Carbamazepine- induced hypertension

From the Division of Neurology (Drs. Jette and Guberman) and Department of Pharmacy (T. Veregin), The Ottawa Hospital, University of Ottawa, Ontario, Canada.

Address correspondence and reprint requests to Dr. Alan Guberman, Professor of Neurology and Director of the Neurology Department and Neurology Residency Training Program, Ottawa Hospital General Campus, Department of Neurology, 501 Smyth Road, Ottawa (ON) K1H 8L6, Canada; aguberman{at}ottawahospital.on.ca

A 33-year-old man with complex partial seizures developed de novo hypertension after the initiation of carbamazepine, which resolved on discontinuation. Although rare, a variety of cardiovascular effects including hypertension have been reported with carbamazepine. Numerous mechanisms may be responsible; however, shared pharmacologic properties with the tricyclic antidepressants are suspect. Hypertension is a rare side effect of carbamazepine.