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Neurology 2002;59:282-284
© 2002 American Academy of Neurology
Brief Communications

Multifocal motor neuropathy and Campylobacter jejuni reactivity

Fabrizia Terenghi, MD, Silvia Allaria, BS, Guglielmo Scarlato, MD and Eduardo Nobile–Orazio, MD PhD

From the "Giorgio Spagnol" Service of Clinical Neuroimmunology, Department of Neurological Sciences, Dino Ferrari Center, Milan University, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.

Address correspondence and reprint requests to Dr. Eduardo Nobile–Orazio, Department of Neurological Sciences, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy; e-mail: eduardo.nobile{at}unimi.it

In some patients, Campylobacter jejuniinfection has been associated with the development of multifocal motor neuropathy (MMN) and high titers of antiganglioside antibodies. The authors measured anti–C. jejuni antibodies by ELISA and immunoblot in 20 patients with MMN, and correlated their presence with antiganglioside reactivity and a history of recent diarrhea. Only one patient had high titers of anti–C. jejuni antibodies, indicating that C. jejuni is unlikely to be involved in the pathogenesis of MMN in most patients.




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