Neurology®
The most widely read and highly cited peer-reviewed Neurology journal
Quick Search
Advanced Search
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Baser, M. E.
Right arrow Articles by Testa, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Baser, M. E.
Right arrow Articles by Testa, J. R.
Related Collections
Right arrow All Oncology
Right arrow All Genetics
Right arrow Neurofibromatosis

Neurology 2002;59:290-291
© 2002 American Academy of Neurology
Brief Communications

Neurofibromatosis 2 and malignant mesothelioma

M. E. Baser, PhD, A. De Rienzo, PhD, D. Altomare, PhD, B. R. Balsara, PhD, N. M. Hedrick, BS, D. H. Gutmann, MD PhD, L. H. Pitts, MD, R. K. Jackler, MD and J. R. Testa, PhD

From Los Angeles, CA (Dr. Baser); Human Genetics Program (Drs. De Rienzo, Altomare, Balsara, and Testa), Fox Chase Cancer Center, Philadelphia, PA; Department of Neurology (N. Hedrick and Dr. Gutmann), Washington University School of Medicine, St. Louis, MO; and Departments of Neurological Surgery (Drs. Jackler and Pitts) and Otolaryngology (Dr. Jackler), University of California, San Francisco.

Address correspondence and reprint requests to Dr. Michael E. Baser, 2257 Fox Hills Drive, Los Angeles, CA 90064; e-mail: baser{at}earthlink.net

Mutations of the neurofibromatosis 2 (NF2) tumor suppressor gene cause the inherited disorder NF2 and are also common in malignant mesothelioma, which is not a characteristic feature of NF2. The authors report an asbestos-exposed person with NF2 and malignant mesothelioma. Immunohistochemical analysis of the mesothelioma confirmed loss of expression of the NF2 protein, and comparative genomic hybridization revealed losses of chromosomes 14, 15, and 22, and gain of 7. The authors propose that a person with a constitutional mutation of an NF2 allele is more susceptible to mesothelioma.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
D. A. Altomare, C. A. Vaslet, K. L. Skele, A. De Rienzo, K. Devarajan, S. C. Jhanwar, A. I. McClatchey, A. B. Kane, and J. R. Testa
A Mouse Model Recapitulating Molecular Features of Human Mesothelioma
Cancer Res., September 15, 2005; 65(18): 8090 - 8095.
[Abstract] [Full Text] [PDF]