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Neurology 2002;59:290-291
© 2002 American Academy of Neurology
Brief Communications

Neurofibromatosis 2 and malignant mesothelioma

M. E. Baser, PhD, A. De Rienzo, PhD, D. Altomare, PhD, B. R. Balsara, PhD, N. M. Hedrick, BS, D. H. Gutmann, MD PhD, L. H. Pitts, MD, R. K. Jackler, MD and J. R. Testa, PhD

From Los Angeles, CA (Dr. Baser); Human Genetics Program (Drs. De Rienzo, Altomare, Balsara, and Testa), Fox Chase Cancer Center, Philadelphia, PA; Department of Neurology (N. Hedrick and Dr. Gutmann), Washington University School of Medicine, St. Louis, MO; and Departments of Neurological Surgery (Drs. Jackler and Pitts) and Otolaryngology (Dr. Jackler), University of California, San Francisco.

Address correspondence and reprint requests to Dr. Michael E. Baser, 2257 Fox Hills Drive, Los Angeles, CA 90064; e-mail: baser{at}earthlink.net

Mutations of the neurofibromatosis 2 (NF2) tumor suppressor gene cause the inherited disorder NF2 and are also common in malignant mesothelioma, which is not a characteristic feature of NF2. The authors report an asbestos-exposed person with NF2 and malignant mesothelioma. Immunohistochemical analysis of the mesothelioma confirmed loss of expression of the NF2 protein, and comparative genomic hybridization revealed losses of chromosomes 14, 15, and 22, and gain of 7. The authors propose that a person with a constitutional mutation of an NF2 allele is more susceptible to mesothelioma.




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D. A. Altomare, C. A. Vaslet, K. L. Skele, A. De Rienzo, K. Devarajan, S. C. Jhanwar, A. I. McClatchey, A. B. Kane, and J. R. Testa
A Mouse Model Recapitulating Molecular Features of Human Mesothelioma
Cancer Res., September 15, 2005; 65(18): 8090 - 8095.
[Abstract] [Full Text] [PDF]


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