| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Division of Geriatrics (Drs. Weaver, Huang, and Seeman), UCLA School of Medicine, Los Angeles, CA; Department of Psychiatry/Gerontology (Dr. Albert), Massachusetts General Hospital, Harvard Medical School, Boston; Office of Geriatric Epidemiology (Dr. Harris), National Institute on Aging, Bethesda, MD; and Mount Sinai Medical School (Dr. Rowe), New York, NY.
Address correspondence and reprint requests to Dr. Teresa E. Seeman, Division of Geriatrics, UCLA School of Medicine, 10945 Le Conte Ave., Suite 2339, Los Angeles, CA 90095-1687; e-mail: tseeman{at}mednet.ucla.edu
Objective: To investigate whether plasma interleukin-6 (IL-6) is cross-sectionally related to poorer cognitive function and whether a baseline plasma IL-6 measurement can predict risk for decline in cognitive function in longitudinal follow-up of a population-based sample of nondisabled elderly people.
Methods: A prospective cohort study of 779 high-functioning men and women aged 70 to 79 from the MacArthur Study of Successful Aging was conducted. Regression modeling was used to investigate whether baseline IL-6 levels (classified by tertiles) were associated with initial cognitive function and whether IL-6 levels predicted subsequent declines in cognitive function from 1988 to 1991 (2.5-year follow-up) and from 1988 to 1995 (7-year follow-up).
Results: Subjects in the highest tertile for plasma IL-6 were marginally more likely to exhibit poorer baseline cognitive function (i.e., scores below the median), independent of demographic status, social status, health and health behaviors, and other physiologic variables (odds ratio [OR] = 1.46; 95% CI: 0.97, 2.20). At 2.5 years, those in both the second tertile of IL-6 (OR = 2.21; 95% CI: 1.44, 3.42) and the third tertile (OR = 2.03; 95% CI: 1.30, 3.19) were at increased risk of cognitive decline even after adjusting for all confounders. At 7 years of follow-up, only those in the highest IL-6 tertile were significantly more likely to exhibit declines in cognition (OR = 1.90; 95% CI: 1.14, 3.18) after adjustment for all confounders.
Conclusions: The results suggest a relationship between elevated baseline plasma IL-6 and risk for subsequent decline in cognitive function. These findings are consistent with the hypothesized relationship between brain inflammation, as measured here by elevated plasma IL-6, and neuropathologic disorders.
This article has been cited by other articles:
|
|
 |
|
  M. Dayhoff-Brannigan, L. Ferrucci, K. Sun, L. P. Fried, J. Walston, R. Varadhan, J. M. Guralnik, and R. D. Semba Oxidative Protein Damage Is Associated With Elevated Serum Interleukin-6 Levels Among Older Moderately to Severely Disabled Women Living in the Community J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2008; 63(2): 179 - 183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Alley, E. M. Crimmins, A. Karlamangla, P. Hu, and T. E. Seeman Inflammation and Rate of Cognitive Change in High-Functioning Older Adults J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2008; 63(1): 50 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Wu, B. L. Plassman, J. Liang, and L. Wei Cognitive Function and Dental Care Utilization Among Community-Dwelling Older Adults Am J Public Health, December 1, 2007; 97(12): 2216 - 2221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Desquilbet, L. P. Jacobson, L. P. Fried, J. P. Phair, B. D. Jamieson, M. Holloway, J. B. Margolick, and for the Multicenter AIDS Cohort Study HIV-1 Infection Is Associated With an Earlier Occurrence of a Phenotype Related to Frailty J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2007; 62(11): 1279 - 1286. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Dik, C. Jonker, H. C. Comijs, D. J.H. Deeg, A. Kok, K. Yaffe, and B. W. Penninx Contribution of Metabolic Syndrome Components to Cognition in Older Individuals Diabetes Care, October 1, 2007; 30(10): 2655 - 2660. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Raji, C. A. Reyes-Ortiz, Y.-F. Kuo, K. S. Markides, and K. J. Ottenbacher Depressive Symptoms and Cognitive Change in Older Mexican Americans J Geriatr Psychiatry Neurol, September 1, 2007; 20(3): 145 - 152. [Abstract] [PDF]
|
|
|
|
 |
|
 A. S. Buchman, P. A. Boyle, R. S. Wilson, Y. Tang, and D. A. Bennett Frailty is Associated With Incident Alzheimer's Disease and Cognitive Decline in the Elderly Psychosom Med, June 1, 2007; 69(5): 483 - 489. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Chodosh, D. M. Kado, T. E. Seeman, and A. S. Karlamangla Depressive Symptoms as a Predictor of Cognitive Decline: MacArthur Studies of Successful Aging Am J Geriatr Psychiatry, May 1, 2007; 15(5): 406 - 415. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Scarmeas, Y. Stern, R. Mayeux, and J. A. Luchsinger Mediterranean Diet, Alzheimer Disease, and Vascular Mediation Arch Neurol, December 1, 2006; 63(12): 1709 - 1717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Marsland, K. L. Petersen, R. Sathanoori, M. F. Muldoon, S. A. Neumann, C. Ryan, J. D. Flory, and S. B. Manuck Interleukin-6 Covaries Inversely With Cognitive Performance Among Middle-Aged Community Volunteers Psychosom Med, November 1, 2006; 68(6): 895 - 903. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. L. Sparkman, J. B. Buchanan, J. R. R. Heyen, J. Chen, J. L. Beverly, and R. W. Johnson Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layers. J. Neurosci., October 18, 2006; 26(42): 10709 - 10716. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Dziedzic Systemic inflammatory markers and risk of dementia. American Journal of Alzheimer's Disease and Other Dementias, August 1, 2006; 21(4): 258 - 262. [Abstract] [PDF]
|
|
|
|
|
|
A. Alfaro-Acha, S. A. Snih, M. A. Raji, Y.-F. Kuo, K. S. Markides, and K. J. Ottenbacher Handgrip strength and cognitive decline in older mexican americans. J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2006; 61(8): 859 - 865. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. E. Finch A perspective on sporadic inclusion-body myositis: The role of aging and inflammatory processes Neurology, January 24, 2006; 66(1_suppl_1): S1 - S6. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Buchman, R. S. Wilson, J. L. Bienias, R. C. Shah, D. A. Evans, and D. A. Bennett Change in body mass index and risk of incident Alzheimer disease Neurology, September 27, 2005; 65(6): 892 - 897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Ravaglia, P. Forti, F. Maioli, N. Brunetti, M. Martelli, L. Servadei, L. Bastagli, M. Bianchin, and E. Mariani Serum C-Reactive Protein and Cognitive Function in Healthy Elderly Italian Community Dwellers J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2005; 60(8): 1017 - 1021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Wikby, F. Ferguson, R. Forsey, J. Thompson, J. Strindhall, S. Lofgren, B.-O. Nilsson, J. Ernerudh, G. Pawelec, and B. Johansson An Immune Risk Phenotype, Cognitive Impairment, and Survival in Very Late Life: Impact of Allostatic Load in Swedish Octogenarian and Nonagenarian Humans J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2005; 60(5): 556 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Dik, C. Jonker, C. E. Hack, J. H. Smit, H. C. Comijs, and P. Eikelenboom Serum inflammatory proteins and cognitive decline in older persons Neurology, April 26, 2005; 64(8): 1371 - 1377. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. N. Abrous, M. Koehl, and M. Le Moal Adult Neurogenesis: From Precursors to Network and Physiology Physiol Rev, April 1, 2005; 85(2): 523 - 569. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Ferrucci, A. Corsi, F. Lauretani, S. Bandinelli, B. Bartali, D. D. Taub, J. M. Guralnik, and D. L. Longo The origins of age-related proinflammatory state Blood, March 15, 2005; 105(6): 2294 - 2299. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S C BONDY, D K LAHIRI, V M PERREAU, K Z SHARMAN, A CAMPBELL, J ZHOU, and E H SHARMAN Retardation of Brain Aging by Chronic Treatment with Melatonin Ann. N.Y. Acad. Sci., December 1, 2004; 1035(1): 197 - 215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Melamed, A. Shirom, S. Toker, S. Berliner, and I. Shapira Association of Fear of Terror With Low-Grade Inflammation Among Apparently Healthy Employed Adults Psychosom Med, July 1, 2004; 66(4): 484 - 491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Engelhart, M. I. Geerlings, J. Meijer, A. Kiliaan, A. Ruitenberg, J. C. van Swieten, T. Stijnen, A. Hofman, J. C. M. Witteman, and M. M. B. Breteler Inflammatory Proteins in Plasma and the Risk of Dementia: The Rotterdam Study Arch Neurol, May 1, 2004; 61(5): 668 - 672. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Monje, H. Toda, and T. D. Palmer Inflammatory Blockade Restores Adult Hippocampal Neurogenesis Science, December 5, 2003; 302(5651): 1760 - 1765. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Rosenkranz, D. C. Jackson, K. M. Dalton, I. Dolski, C. D. Ryff, B. H. Singer, D. Muller, N. H. Kalin, and R. J. Davidson Affective style and in vivo immune response: Neurobehavioral mechanisms PNAS, September 16, 2003; 100(19): 11148 - 11152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yaffe, K. Lindquist, B. W. Penninx, E. M. Simonsick, M. Pahor, S. Kritchevsky, L. Launer, L. Kuller, S. Rubin, and T. Harris Inflammatory markers and cognition in well-functioning African-American and white elders Neurology, July 8, 2003; 61(1): 76 - 80. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Elevated IL-6 Levels Associated with Cognitive Decline Journal Watch Psychiatry, November 6, 2002; 2002(1106): 5 - 5. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
