HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Jagust, W. J. Articles by Haan, M. N. Search for Related Content PubMed PubMed Citation Articles by Jagust, W. J. Articles by Haan, M. N. Related Collections All Imaging PET All Neuropsychology/Behavior All Cognitive Disorders/Dementia Alzheimer's disease Cognitive aging Assessment of cognitive disorders/dementia

Brain function and cognition in a community sample of elderly Latinos

From the Department of Neurology (Drs. Jagust, Eberling, and Mungas, C. Wu and A. Finkbeiner) and Center for Neuroscience (Drs. Jagust and Eberling, C. Wu and A. Finkbeiner), University of California, Davis; Northern California PET Imaging Center (P. Valk), Sacramento; and Department of Epidemiology (Dr. Haan), University of Michigan, Ann Arbor.

Address correspondence and reprint requests to Dr. William Jagust, Department of Neurology, University of California Davis Medical Center, 4860 Y Street, Suite 3700, Sacramento, CA 95817; e-mail: wjjagust{at}ucdavis.edu

Background: Previous studies using PET to measure cerebral glucose metabolism in AD have found metabolic reductions in the temporoparietal and posterior cingulate cortices in individuals with dementia and those at risk of developing it. This study was designed to extend this finding to individuals selected from a population-based cohort of Mexican Americans with a wide spectrum of cognitive ability.

Methods: A group of 93 individuals was selected from the Sacramento Area Latino Study on Aging, and subjects were categorized into four groups of increasing levels of cognitive impairment: normal, memory impaired, cognitively impaired but not demented (CIND), and demented. PET was performed with the tracer [¹⁸F]-fluorodeoxyglucose, and data were analyzed with both statistical parametric mapping and an atrophy-corrected volume of interest approach.

Results: Individuals with dementia had metabolic reductions that were most robust in the posterior cingulate cortex, whereas CIND subjects had less statistically robust reductions in the posterior cingulate cortex. Cingulate hypometabolism increased the risk of dementia and was a significant risk factor for dementia in logistic regression models that also incorporated MR measures of hippocampal volume and white matter hyperintensities.

Conclusion: Posterior cingulate cortical hypometabolism is clearly detected in individuals with dementia who are selected from a population with lower education and a high prevalence of cerebrovascular risk factors, supporting the generalizability of this finding. These metabolic reductions occur prior to the onset of dementia but only in those persons with relatively advanced symptoms.

This article has been cited by other articles:

				K A Johnson, E K Moran, J A Becker, D Blacker, A J Fischman, and M S Albert Single photon emission computed tomography perfusion differences in mild cognitive impairment J. Neurol. Neurosurg. Psychiatry, March 1, 2007; 78(3): 240 - 247. [Abstract] [Full Text] [PDF]

				D. H.S. Silverman Brain 18F-FDG PET in the Diagnosis of Neurodegenerative Dementias: Comparison with Perfusion SPECT and with Clinical Evaluations Lacking Nuclear Imaging J. Nucl. Med., April 1, 2004; 45(4): 594 - 607. [Abstract] [Full Text] [PDF]