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Neurology 2002;59:438-440
© 2002 American Academy of Neurology
Brief Communications

Multiple risk factors in neonatal sinovenous thrombosis

Y. W. Wu, MD, MPH, S. P. Miller, MD, K. Chin, BA, A. E. Collins, MD, S. C. Lomeli, BS, N. A. Chuang, MD, A. J. Barkovich, MD and D. M. Ferriero, MD

From the Departments of Neurology (Drs. Wu, Miller, and Ferriero, K. Chin, and S. Lomeli), Pediatrics (Dr. Wu, Collins, Barkovich, and Ferriero), and Radiology (Drs. Chuang and Barkovich), University of California, San Francisco.

Address correspondence and reprint requests to Dr. Yvonne Wu, Department of Child Neurology, Box 0136, University of California, San Francisco, 500 Parnassus Ave., Rm 412, San Francisco, CA 94143-0136; e-mail: yvonne{at}itsa.ucsf.edu

The etiology of neonatal sinovenous thrombosis is poorly understood. The authors report the risk factors and radiologic features of neonatal sinovenous thrombosis seen over an 11-year period. Of 30 patients, 29% received extracorporeal membrane oxygenation treatment, and 23% had congenital heart disease. Genetic thrombophilias were present in four of the seven infants tested. Eighteen neonates had multiple maternal, neonatal, perinatal, or prothrombotic complications. Sinovenous thrombosis was often accompanied by infarction (50%) or intraventricular hemorrhage (33%).




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